Comparative analysis of hepatocellular carcinoma in men and dogs [Komparativna analiza hepatocelularnih karcinom ljudi i pasa]

Grabarević, Željko and Ćorić, Marijana and Seiwerth, Sven and Džaja, Petar and Artuković, Branka and Gudan Kurilj, Andrea and Beck, Ana and Hohšteter, Marko and Šoštarić-Zuckermann, Ivan-Conrado and Brčić, Luka and Hrstić, Irena (2009) Comparative analysis of hepatocellular carcinoma in men and dogs [Komparativna analiza hepatocelularnih karcinom ljudi i pasa]. Collegium Antropologicum, 33 (3). pp. 811-814. ISSN 0350-6134

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Abstract

Concerning the important differences in the ethiopathology of hepatocelular carcinomas (HCC) in humans and dogs, our work describes the expression of epidermal growth factor receptor (EGFr), cytokeratine 19 (CK19), vascular endothelial growth factor (VEGF) and transforming growth factor beta receptor (TGFb-r) in tumors arising in both species. Investigation included 25 cases of human and 8 cases of dog tumors. All human cases were noted in cirrhotic livers, while in dogs the tissue adjacent to tumor was not changed. In humans in two cases hepatitis B virus (HBV) and in one case hepatitis C virus (HCV) were determined. Investigation showed lack of TGFb-r reaction in six cases of canine HCC, while in humans only one case was negative. In most tumors specific hepatocyte antigen Hepatocyte Paraffin 1 marker (Hep Par 1) was mainly positive with markedly decreased reaction compared to the normal hepatocytes, while cytokeratine 19 for billiary epithelium was negative. The result of our investigation rise the question about the possible role of tumor suppressor gene TGFb-r in the development of HCC in dogs and in the same time emphasizes its importance in human diseases.

Abstract in Croatian

S obzirom na značajne razlike etiopatologije hepatocelularnih carcinoma (HCC) ljudi i pasa, naš rad opisuje ekspresiju receptora epidermalnog faktora rasta (EGFr), citokeratina 19 (CK19), faktora rasta podrijetla vaskularnog endotela (VEGF) i receptora za transformirajući factor rasta beta (TGFb-r) u obje vrste. Istraživanje je obuhvatilo 25 slučajeva HCC u ljudi i 8 slučajeva HCC u pasa. U ljudi se ovaj tumor u svim slučajevima pojavio u jetri zahvaćenoj cirotičnim promjenama, dok je u pasa dio jetre nezahvaćen tumorom bio nepromijenjen. U ljudi je u dva slučaja utvrđena infekcija s virusom hepatitisa B, a u jednom s virusom hepatitisa C. Istraživanje je pokazalo izostanak reakcija na TGFb-r u šest tumora pasa, dok je ova reakcija izostala samo u jednom tumoru ljudi. Hepatocitni antigen Hep Par 1 je u većini tumora bio pozitivan sa značajno smanjenim intenzitetom reakcije u usporedbi s normalnim hepatocitima, dok je CK19 specifičan za bilijarni epitel bio negativan. Rezultati istraživanja ukazuju na značenje TGFb-r u nastanku HCC u pasa i istodobno naglašavaju njegovo značenje u ovom tumoru ljudi.

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