Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide

Štefulj, Jasminka and Mokrović, Gordana and Hranilović, Dubravka and Bordukalo-Nikšić, Tatjana and Bakula, Mirko and Kubat, Milovan and Jernej, Branimir (2010) Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide. Psychiatry Research, 186 (2-3). pp. 446-447. ISSN 0165-1781

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Official URL: https://doi.org/10.1016/j.psychres.2010.08.034

Abstract

The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion.

Item Type:

Article

MeSH:

Chi-Square Distribution ; Cohort Studies ; Croatia / epidemiology ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Polymorphism, Genetic / genetics ; Promoter Regions, Genetic / genetics ; Self-Injurious Behavior / genetics ; Suicide ; Tryptophan Hydroxylase / genetics

Departments:

Hrvatski institut za istraživanje mozga
Katedra za sudsku medicinu

Depositing User:

Marijan Šember

Status:

Published

Creators:

Creators	Email
Štefulj, Jasminka	UNSPECIFIED
Mokrović, Gordana	UNSPECIFIED
Hranilović, Dubravka	UNSPECIFIED
Bordukalo-Nikšić, Tatjana	UNSPECIFIED
Bakula, Mirko	UNSPECIFIED
Kubat, Milovan	UNSPECIFIED
Jernej, Branimir	UNSPECIFIED

Date:

30 April 2010

Date Deposited:

27 Oct 2010

Last Modified:

14 Jul 2020 09:25

Subjects:

Related URLs:

Publisher

URI:

http://medlib.mef.hr/id/eprint/870

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