Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer [Vaskularni endotelni čimbenik rasta i gustoća tumorskih kapilara kao prognostički čimbenik u endometrijskom raku]

Topolovec, Zlatko and Ćorušić, Ante and Babić, Damir and Mrčela, Milanka and Šijanović, Siniša and Müller-Vranješ, Andrijana and Čuržik, Darko (2010) Vascular endothelial growth factor and intratumoral microvessel density as prognostic factors in endometrial cancer [Vaskularni endotelni čimbenik rasta i gustoća tumorskih kapilara kao prognostički čimbenik u endometrijskom raku]. Collegium Antropologicum, 34 (2). pp. 447-453. ISSN 0350-6134

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Abstract

The aim of this research was to determine the VEGF A expression in tumor cells and the intratumoral microvessel density and their prognostic significance in the survival of the subjects. 87 subjects were monitored retrospectively for a period of 60 to 132 months. The subjects were treated at the Department of Obstetrics and Gynecology of Osijek University Hospital Center, Croatia. We analysed standard clinical, pathohistological and therapeutical prognostic factors, intratumoral microvessel density and expression of VEGF A. Five-year survival was calculated by the life chart method and presented graphically by Kaplan-Meier curves. Reaching conclusions on statistical hypotheses in this paper was done with a reliability level p < 0.05. Of the analyzed clinical prognostic factors, those which proved to be statistically significant and independent prognostic factors were age and clinical stage of the disease, and of pathohistologic ones it was the depth of myometrial invasion and VEGF expression. An elevated VEGF expression is associated with deep myometrial invasion, poorly differentiated tumors, histologic type and intratumoral microvessel density to a statistically significant degree. Elevated VEGF expression, age, FIGO stage and depth of myometrial invasion play a significant prognostic role in patients with endometrial cancer. VEGF receptors could be a target for adjuvant therapy in VEGF positive endometrial cancer.

Abstract in Croatian

Cilj ovog istraživanja bio je odrediti genski izražaj VEGF A u tumorskim stanicama i vrijednosti tumorske gustoće kapilara i njihov prognostički značaj za preživljenje ispitanica. Retrospektivno je kroz period od 60 do 132 mjeseca praćeno 87 ispitanica, liječenih u Odjelu za ginekologiju i porodništvo Kliničke bolnice Osijek, Hrvatska. Analizirali smo standardne kliničke, patohistološke i terapijske prognostičke čimbenike, gustoću tumorskih kapilara i izražaj VEGF A. Vjerojatnost preživljenja računali smo metodom životnih tablica i prikazali je grafički Kaplan-Meierovim krivuljama. Zaključivanje o statističkim hipotezama u ovom je radu provedeno uz razinu sigurnosti p<0,05. Od analiziranih klini- čkih prognostičkih čimbenika statistički značajnim i neovisnim prognostičkim čimbenicima pokazali su se dob i klinički stadij bolesti, a od patohistoloških, dubina miometrijske invazije i izražaj VEGF-a. Povišen izražaj VEGF-a statistički je značajno povezan s dubokom miometrijskom invazijom, slabo diferenciranim tumorima, histološkim tipom tumora i gustoćom tumorskih kapilara. Povećan genski izražaj VEGF-a, dob, FIGO stadij i dubina miometrijske invazije imaju značajnu prognostičku ulogu u bolesnica s endometrijskim rakom. VEGF receptori bi mogli biti meta adjuvantne terapije u VEGF pozitivnim karcinomima endometrija.

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