Detection of human papillomaviruses type 16, 18 and 33 in bronchial aspirates of lung carcinoma patients by polymerase chain reaction: a study of 84 cases in Croatia [Određivanje humanog papiloma virusa tipa 16, 18 i 33 u aspiratima bronha pacijenata s karcinomom pluća metodom lančane reakcije polimerazom: istraživanje 84 pacijenta u Hrvatskoj]

Vrabec Branica, Božica and Smojver-Ježek, Silvana and Juroš, Zrinka and Grgić, Sandra and Srpak, Nives and Mitrečić, Dinko and Gajović, Srećko (2010) Detection of human papillomaviruses type 16, 18 and 33 in bronchial aspirates of lung carcinoma patients by polymerase chain reaction: a study of 84 cases in Croatia [Određivanje humanog papiloma virusa tipa 16, 18 i 33 u aspiratima bronha pacijenata s karcinomom pluća metodom lančane reakcije polimerazom: istraživanje 84 pacijenta u Hrvatskoj]. Collegium Antropologicum, 34 (1). pp. 159-162. ISSN 0350-6134

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Abstract

Besides its well-known role in cervical carcinoma, HPV is also suggested to be involved in lung cancer development. A number of authors have been investigating the presence of HPV in histological materials. We used routine bronchial aspirates from 84 patients with lung carcinoma for DNA extraction and then performed polymerase chain reaction for high-risk HPV types 16, 18 and 33. The results were compared to those obtained from buccal and eyelid mucosa. Only three patients were positive for HPV in bronchial aspirates: one for HPV 16 type, one for HPV 18 type, and one for HPV 33. Our data indicated the low prevalence of HPV in patients with lung carcinomas in Croatia, therefore it seems unlikely that HPV contributes to the development of lung carcinomas in this region.

Abstract in Croatian

Za humani papiloma virus je pretpostavljeno da može imati, osim u etiologiji karcinoma cerviksa uterusa, ulogu i u etiologiji nastanka karcinoma pluća. Prisustvo visokorizičnih tipova papiloma virusa tipa 16, 18 i 33 istraživano je u rutinskim citološkim uzorcima aspirata bronha 84 pacijenata s karcinomom pluća, nakon izolacije DNA, metodom lančane reakcije polimerazom. Rezultati su uspoređivani sa onima u uzorcima bukalne i vjeđne sluznice. Samo tri pacijenta bila su pozitivna na humani papiloma virus: jedan na HPV 16 tip, jedan na HPV 18 tip i jedan na HPV 33 tip. Naši rezultati potvrđuju nisku prevalenciju humanog papiloma virusa u pacijenata s plućnim karcinomom u Hrvatskoj što ukazuje da HPV vjerojatno ne sudjeluje u razvoju karcinoma pluća na ovom području.

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