Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients

Polašek, Ozren and Gunjača, Grgo and Kolčić, Ivana and Zgaga, Lina and Džijan, Snježana and Smolić, Robert and Smolić, Martina and Milas-Ahić, Jasminka and Šerić, Vatroslav and Galić, Josip and Tucak-Zorić, Sandra and Tucak, Antun and Rudan, Igor and Lauc, Gordan (2010) Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. Croatian Medical Journal, 51 (1). pp. 48-53. ISSN 0353-9504

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Abstract

Aim. To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. ----- Methods. A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). ----- Results. There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. ----- Conclusion. Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

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