Nucleolar protein 1 (Nol1) expression in the mouse brain

Mitrečić, Dinko and Malnar, Tajana and Gajović, Srećko (2008) Nucleolar protein 1 (Nol1) expression in the mouse brain. Collegium Antropologicum, 32 (S. 1). pp. 123-126. ISSN 0350-6134

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Abstract

Nucleolar protein 1 (Nol1) is a cell cycle dependent gene highly expressed in proliferating tissues. In order to test whether Nol1 could be used as a marker of dividing neural stem cells within mouse brain, Nol1 expression was analyzed using mouse carrying a gene trap modification of Nol1 gene. High Nol1 expression was found within the hippocampus, olfactory bulb, cerebral and cerebellar cortex. Nol1 was expressed not only in the dividing cells within the brain, but as well in the postmitotic neurons. This suggested a general role of Nol1 in assembling of ribosomes in cells with high protein production.

Abstract in Croatian

Bjelančevina jezgrice 1 (Nucleolar protein 1, Nol1) je gen izražen u stanicama koje se umnažaju, te mu izražaj ovisi o fazi staničnog ciklusa. Kako bismo testirali hipotezu da je Nol1 potencijalni biljeg stanica u diobi u mozgu miša (živčane matične stanice), analizirali smo izražaj Nol1 u mozgu miša kojem je Nol1 preinačen postupkom genske zamke. Ekspresija Nol1 je nađena u hipokampusu, njušnom bulbusu, te u kori velikog i malog mozga. Ovaj nalaz je ukazao da Nol1 nije izražen samo u stanicama koje se dijele, već i u diferenciranim živčanim stanicama. Pretpostavljeno je kako Nol1 ima ulogu u sintezi ribosoma i bjelančevina u stanicama živčanog sustava.

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