Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

Svaguša, Tomo and Martinić, Mislav and Martinić, Matea and Kovačević, Lucija and Šepac, Ana and Miličić, Davor and Bulum, Joško and Starčević, Boris and Sirotković-Skerlev, Maja and Seiwerth, Fran and Kulić, Ana and Sedlić, Filip (2020) Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart. Croatian Medical Journal, 61 (2). pp. 126-138. ISSN 0353-9504

PDF - Published Version Download (494kB)

Abstract

Mitochondria are involved in crucial homeostatic processes in the cell: the production of adenosine triphosphate and reactive oxygen species, and the release of pro-apoptotic molecules. Thus, cell survival depends on the maintenance of proper mitochondrial function by mitochondrial quality control. The most important mitochondrial quality control mechanisms are mitochondrial unfolded protein response, mitophagy, biogenesis, and fusion-fission dynamics. This review deals with mitochondrial quality control in heart diseases, especially myocardial infarction and heart failure. Some previous studies have demonstrated that the activation of mitochondrial quality control mechanisms may be beneficial for the heart, while others have shown that it may lead to heart damage. Our aim was to describe the mechanisms by which mitochondrial quality control contributes to heart protection or damage and to provide evidence that may resolve the seemingly contradictory results from the previous studies.

Actions (login required)

View Item

Downloads