Transrektalna elastografija u razlikovanju Crohnove bolesti i ulceroznoga kolitisa [Transrectal elastography in differentiation between Crohn's disease and ulcerative colitis]

Majerović, Matea (2019) Transrektalna elastografija u razlikovanju Crohnove bolesti i ulceroznoga kolitisa [Transrectal elastography in differentiation between Crohn's disease and ulcerative colitis]. PhD thesis, Sveučilište u Zagrebu.

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Abstract

The patterns of inflammation and collagen deposition differ between Crohn's disease (CD) and ulcerative colitis (UC). Assuming that both processes alter the mechanical properties of the bowel wall, its stiffness is a potential discriminatory feature between the two diseases. The aim of this study was to determine whether is it possible to differentiate between active Crohn's colitis, with rectal involvement, and active ulcerative colitis, on the grounds of pseudoquantitative measurements obtained by transrectal ultrasound-guided strain elastography. 28 CD patients, 30 UC patients and 30 controls were enrolled in the study. Regions of interest were placed over the rectal wall and the adjacent perirectal tissue. Relative strain and average Histogram values were measured in every region and Strain Ratio (SR) and Histogram Ratio (HR) were calculated. There were no statistically significant differences in SR and HR between the three groups. The relative rectal wall strain was lower in CB group compared to UC group (P=0,035), average rectal wall Histogram value was higher in CB group compared to UC group but the difference did not reach statistical significance (P=0,067). According to our results, SR and HR measurements do not discriminate between UC and CB, however, relative strain differences between the two groups suggest that strain elastography might have a role in inflammatory bowel disease diagnostics.

Abstract in Croatian

Crohnova bolest (CB) i ulcerozni kolitis (UK) razlikuju po obrascima upale i odlaganja kolagena u stijenku crijeva. Pod pretpostavkom da oba procesa mijenjaju mehanička svojstva stijenke, krutost stijenke njihovo je potencijalno razlikovno svojstvo. Cilj ovog istraživanja bio je utvrditi da li je moguće razlikovati aktivan Crohn kolitis, sa zahvaćanjem rektuma, i aktivan ulcerozni kolitis, temeljem pseudokvantitativnih mjerenja strain elastografije učinjene transrektalnim ultrazvukom. U istraživanje je uključeno 28 ispitanika s CB, 30 ispitanika s UK i 30 zdravih kontrola. Regije interesa postavljene su nad stijenku rektuma i nad perirektalno tkivo neposredno uz stijenku. Mjereni su relativni strainovi i prosječne vrijednosti Histograma u svakoj regiji a potom su izračunati omjeri dobivenih vrijednosti – Strain Ratio (SR) i Histogram Ratio (HR). Nije nađeno statistički značajne razlike između SR-a i HR-a između ispitivanih skupina. Relativni strain stijenke bio je niži u CB skupini u odnosu na UK (P=0,035), prosječna vrijednost Histograma stijenke bila je viša u CB skupini u odnosu na UK ali razlika nije dostigla statističku značajnost (P=0,067). Prema našim rezultatima, temeljem SR-a i HR-a nije moguće razlikovati CB i UK no razlike u relativnim strainovima stijenke rektuma sugeriraju da strain elastografija ima potencijal u dijagnostici upalnih bolesti crijeva.

Item Type: Thesis (PhD)
Mentors:
Mentor
Rustemović, Nadan
Departments: Izvan medicinskog fakulteta
Depositing User: dr.med. Helena Markulin
University: Sveučilište u Zagrebu
Institution: Medicinski fakultet
Number of Pages: 73
Status: Unpublished
Creators:
CreatorsEmail
Majerović, MateaUNSPECIFIED
Date: 11 December 2019
Date Deposited: 08 Sep 2020 08:01
Last Modified: 08 Sep 2020 08:01
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/3643

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