Stryeck, Sarah and Gastrager, Michaela and Degoricija, Vesna and Trbušić, Matias and Potočnjak, Ines and Radulović, Bojana and Pregartner, Gudrun and Berghold, Andrea and Madl, Tobias and Frank, Saša (2019) Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Scientific Reports, 9 (1). ISSN 2045-2322
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Abstract
Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p = 0.005, p = 0.008, p<0.001, and p<0.001, respectively). These associations still remained significant for all tested metabolites except for lactate after adjusting for established prognostic parameters in HF. In conclusion, serum levels of 2-HB, 3-HB, tyrosine, and citrate measured at admission are associated with an increased 3-month mortality rate in AHF patients and might thus be of prognostic value in AHF.
| Item Type: | Article | ||||||||||||||||||||||
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| Additional Information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ||||||||||||||||||||||
| Departments: | Katedra za internu medicinu | ||||||||||||||||||||||
| Depositing User: | Kristina Berketa | ||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||
| Creators: |
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| Date: | 1 May 2019 | ||||||||||||||||||||||
| Date Deposited: | 29 Jan 2020 09:07 | ||||||||||||||||||||||
| Last Modified: | 29 Jan 2020 09:07 | ||||||||||||||||||||||
| Subjects: | / | ||||||||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/3562 |
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