Utjecaj stresa na kliničke manifestacije infekcije humanim papiloma virusom [Influence of stress on clinical manifestations of human papilloma virus infection]

Cvitanović, Hrvoje (2019) Utjecaj stresa na kliničke manifestacije infekcije humanim papiloma virusom [Influence of stress on clinical manifestations of human papilloma virus infection]. PhD thesis, Sveučilište u Zagrebu.

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Abstract

Background: Results of studies which have investigated the relationship between HPV infection and the effects of psychological stress are inconsistent. ----- Objectives: The aim of our study was to examine whether there are differences in the clinical manifestations of HPV infection due to the level of experienced stress. ----- Methods: The study included 213 subjects. The first group had manifested HPV infection and positive stress experience while the control group was patients who had manifested HPV infection with no significantly stressful experience. ----- Results: There were no statistically significant differences with respect to the impact of stress on clincal HPV infection. Significantly higher values of leukocytes, alpha-2 and beta globulins were observed in patients with significant stressful experience. Adaptive coping and lower perception of stress can significantly reduce the chances of belonging to a group that has the extragenital manifestations. The perception of stress significantly increases the likelihood of genital manifestations. ----- Conclusion: It can be concluded that a significant level of experienced stressful events do not influence the clinical incidence of HPV infection. There is impact on the increased value of leukocytes, alpha-2 and beta globulins but alostatic pressure was not strong enough to cause significant changes in susceptibility of HPV infection.

Abstract in Croatian

Rezultati dosadašnjih studija koje su proučavale povezanost HPV infekcije i djelovanja psihičkog stresa nisu konzistentni. ----- Cilj istraživanja: Osnovni cilj naše studije je bio ispitati postoji li razlika u kliničkim manifestacijama HPV infekcije s obzirom na stupanj proživljenog stresa. ----- Metode i materijali: U studiju je bilo uključeno 213 ispitanika. Ispitanici su bili podijeljeni u dvije grupe. Prva grupa s manifestnom HPV infekcijom i značajnim stresnim iskustvom i maladaptivnom reakcijom dok su kontrolnu skupinu činili bolesnici koji imaju manifestnu HPV infekciju i nisu imali značajno stresno iskustvo. ----- Rezultati: Nije bilo statistički značajne razlike s obzirom na utjecaj stresa na kliničke manifestacije infekcije humanim papiloma virusom. Statistički značajno više vrijednosti leukocita, alfa-2 i beta globulina zabilježene u skupini bolesnika sa značajnim stresnim iskustvom. U skupini koja ima izvangenitalne manifestacije utvrđeno je više adaptivnog suočavanja i manji stupanj percepcije stresa. Viši stupanj percepcije stresa značajno povećava vjerojatnost genitalnih manifestacija. ----- Zaključak: Stupanj proživljenih stresnih događaja ne utječe na kliničku pojavnost HPV infekcije. Uz to, postoji utjecaj stresa koji rezultira povišenim vrijednostima leukocita, alfa-2 i beta globulina, no alostatsko opterećenje nije bilo dovoljno jako da bi došlo pojave povećane podložnosti razvoju HPV infekcije.

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