Emergency care of patients receiving non-vitamin K antagonist oral anticoagulants

Eikelboom, J.W. and Kozek-Langenecker, S. and Exadaktylos, A. and Batorova, A. and Boda, Z. and Christory, F. and Gornik, Ivan and Kėkštas, G. and Kher, A. and Komadina, R. and Koval, O. and Mitic, G. and Novikova, T. and Pazvanska, E. and Ratobilska, S. and Sütt, J. and Winder, A. and Zateyshchikov, D. (2018) Emergency care of patients receiving non-vitamin K antagonist oral anticoagulants. British Journal of Anaesthesia, 120 (4). pp. 645-656. ISSN 0007-0912

[img] PDF - Published Version
Download (1MB)

Abstract

Non-vitamin K antagonist oral anticoagulants (NOACs), which inhibit thrombin (dabigatran) and factor Xa (rivaroxaban, apixaban, edoxaban) have been introduced in several clinical indications. Although NOACs have a favourable benefit-risk profile and can be used without routine laboratory monitoring, they are associatedeas any anticoagulantewith a risk of bleeding. In addition, treatment may need to be interrupted in patients who need surgery or other procedures. The objective of this article, developed by a multidisciplinary panel of experts in thrombosis and haemostasis, is to provide an update on the management of NOAC-treated patients who experience a bleeding episode or require an urgent procedure. Recent advances in the development of targeted reversal agents are expected to help streamline the management of NOAC-treated patients in whom rapid reversal of anticoagulation is required.

Item Type: Article
Additional Information: © 2017 The Author(s). Published by Elsevier Ltd on behalf of British Journal of Anaesthesia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
MeSH: Administration, Oral ; Anticoagulants/adverse effects ; Antithrombins/adverse effects ; Emergency Medical Services/methods ; Hemorrhage/chemically induced ; Hemorrhage/therapy ; Humans
Departments: Katedra za internu medicinu
Depositing User: Kristina Berketa
Status: Published
Creators:
CreatorsEmail
Eikelboom, J.W.UNSPECIFIED
Kozek-Langenecker, S.UNSPECIFIED
Exadaktylos, A.UNSPECIFIED
Batorova, A.UNSPECIFIED
Boda, Z.UNSPECIFIED
Christory, F.UNSPECIFIED
Gornik, IvanUNSPECIFIED
Kėkštas, G.UNSPECIFIED
Kher, A.UNSPECIFIED
Komadina, R.UNSPECIFIED
Koval, O.UNSPECIFIED
Mitic, G.UNSPECIFIED
Novikova, T.UNSPECIFIED
Pazvanska, E.UNSPECIFIED
Ratobilska, S.UNSPECIFIED
Sütt, J.UNSPECIFIED
Winder, A.UNSPECIFIED
Zateyshchikov, D.UNSPECIFIED
Date: April 2018
Date Deposited: 20 Sep 2019 07:36
Last Modified: 25 Aug 2020 07:29
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/3363

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year