Histopathological changes in tracheal mucosa following total laryngectomy [Histopatološke promjene trahealne sluznice nakon totalne laringektomije]

Rosso, Marinela and Prgomet, Drago and Marjanović, Ksenija and Pušeljić, Silvija and Tićac, Robert and Mihaljević, Ivan (2016) Histopathological changes in tracheal mucosa following total laryngectomy [Histopatološke promjene trahealne sluznice nakon totalne laringektomije]. Collegium Antropologicum, 40 (2). pp. 123-126. ISSN 0350-6134

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Abstract

The aim of this study was to determine the long term histopathologic changes in tracheal mucosa after a total laryngectomy , and to find out the relationship between the progression of histopathologic changes in tracheal mucosa and the duration of breathing through the tracheostomy. Tracheal mucosal biopsies were taken from a total of 35 patients, of both sexes, who underwent a total laryngectomy for laryngeal carcinoma at least one year prior. Histologic specimens of tracheal mucosa were stained with hematoxylin and eosin and examined under light microscopy. Almost all of the patients demonstrated histopathologic changes or abnormalities. Based on the results, histological findings were grouped into seven categories: normal respiratory epithelium, mild, moderate and advanced basal cell hyperplasia, squamous metaplasia, and slight and moderate and dysplasia. The time elapsed since surgery was calculated for each histopathological change separately. In laryngeal carcinoma patients, after a total laryngectomy histopathologic changes occur in tracheal mucosa. The mildest histopathological changes are found in the patients who had a longer period between the operation and the examination.

Abstract in Croatian

Cilj ovog istraživanja bio je utvrditi kasne histopatološke promjene sluznice traheje nakon totalne laringektomije, te usporediti stupanj progresije histoloških promjena sluznice traheje u odnosu na vrijeme trajanja disanja kroz traheostomu. Bioptički uzorci sluznice traheje uzeti su od ukupno 35 ispitanika oba spola, kojima je zbog karcinoma larinksa učinjena totalna laringektomija najmanje godinu dana prije istraživanja. Histološki preparati obojeni su hemalaun - eozinom i pregledani svjetlosnim mikroskopom. Gotovo u svih ispitanika došlo je do histopatoloških promjena ili abnormalnosti. Temeljem dobivenih rezultata, histološki nalaz sluznice traheje grupiran je u sedam kategorija: normalni respiratorni epitel, blaga, umjerena i jaka hiperplazija bazalnih stanica, pločasta metaplazija i blaga i umjerena displazija. Vrijeme proteklo od operacije izračunato je za svaku patohistološku promjenu posebno. Kod bolesnika oboljelih od karcinoma larinksa, nakon totalne laringektomije dolazi do histopatoloških promjena sluznice traheje. Najblaže histopatološke promjene nađene su u bolesnika kod kojih je prošlo duže vremensko razdoblje između operacije i istraživanja.

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