Uspješna primjena adalimumaba u bolesnice oboljele od reumatoidnog artritisa i primarne bilijarne ciroze [A patient with rheumatoid arthritis and primary biliary cirrhosis successfully treated with adalimumab]

Bakula, Marija and Mayer, Miroslav and Čikeš, Nada and Anić, Branimir (2015) Uspješna primjena adalimumaba u bolesnice oboljele od reumatoidnog artritisa i primarne bilijarne ciroze [A patient with rheumatoid arthritis and primary biliary cirrhosis successfully treated with adalimumab]. Liječnički vjesnik, 137 (1-2). pp. 27-29. ISSN 0024-3477

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Abstract

Rheumatoid arthritis and primary biliary cirrhosis coexist in up to 6% of cases. Tumor necrosis factor alpha seems to have an important role in the pathogenesis of both diseases. Tumor necrosis factor alpha inhibitors have become an established therapeutic regimen for patients with rheumatoid arthritis. The only approved drug for primary biliary cirrhosis is ursodeoxycholic acid. We describe the case of a female patient with both rheumatoid arthritis and primary biliary cirrhosis in a long term remission of both diseases induced with adalimumab. This case report is an important addendum to a few published similar reports.

Abstract in Croatian

Bolesnici oboljeli od reumatoidnog artritisa u oko 6% slučajeva mogu istodobno bolovati i od primarne bilijarne ciroze. Čini se da faktor tumorske nekroze alfa (TNF-a) ima važnu ulogu u patogenezi obiju bolesti. Inhibitori TNF-a registrirani su za liječenje reumatoidnog artritisa. Jedini odobreni lijek za liječenje primarne bilijarne ciroze jest ursodeoksikolna kiselina. Prikazan je slučaj bolesnice oboljele od reumatoidnog artritisa i primarne bilijarne ciroze, koja je uz terapiju adalimumabom postigla dugotrajnu remisiju obiju bolesti. Ovaj prikaz bolesnice važan je dodatak uz nekoliko do sada objavljenih sličnih slučajeva.

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