Petričević, Nina (2016) Promjena koncentracije hormona grelina i PYY i uhranjenosti djece nakon godinu dana [Changes in ghrelin and PYY and weight status in children after a one year follow up]. PhD thesis, Sveučilište u Zagrebu.
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Abstract
Aim: To investigate ghrelin and PYY levels, their association with anthropometric measures, puberty and living habits, and to evaluate hormone levels and weight status at the beginning and after a one year follow up. Materials and methods: Sample of 100 children (56 female, 44 male, mean age 13,3 years) selected by a randomized procedure of children born on specific year from the area of school health service Siget, Novi Zagreb. Methods: physical exam and anthropometric measures, ghrelin and PYY hormone analysis and questionnaire on living habits. Data were analysed by multivariate logistic regression models by gender. Results: We found negative correlation between ghrelin and BMI z score (r = -0,25, p = 0,011), body weight (r = -0,27; p = 0,007), waist circumference (r = -0,27; p = 0,006), hip circumference (r = -0,23; p = 0,021), triceps skinfold thickness (r = 0,29; p = 0,003) and subscapular skinfold thickness (r = -0,25; p = 0,003). Ghrelin correlates negatively with puberty. PYY levels are not correlated with weight status, anthropometric measurements or puberty. Ghrelin levels are significantly lower after a one year follow up, and there is no change in PYY levels. Conclusion: Ghrelin is lower among overweight and obese children and PYY does not correlate with weight status. After a one year follow up in free living conditions, there is significant change in ghrelin levels (significantly lower) and no change in PYY levels.
Abstract in Croatian
Cilj: Odrediti koncentracije hormona grelina i PYY, ispitati povezanost razine hormona s antropometrijskim mjerenjima, pubertetom i životnim navikama te analizirati početnu razinu hormona i uhranjenosti djece te razine hormona i uhranjenosti nakon godinu dana. Materijali i metode: Randomizirani uzorak djece jednog godišta s područja odsjeka Službe za školsku i sveučilišnu medicinu Novi Zagreb, 100 djece (56 Ž i 44 M, srednja dob 13.3 godine). Metode: liječnički pregled i antropometrijska mjerenja, određivanje hormona grelina i PYY te upitnik o životnim navikama. Analizirano modelima multivarijatne logističke regresije prema spolu. Rezultati: Koncentracija grelina značajno negativno korelira s ITM z skorom (r = -0,25, p = 0,011), tjelesnom masom (r = -0,27; p = 0,007), opsegom struka (r = -0,27; p = 0,006), opsegom bokova (r = -0,23; p = 0,021), kožnim naborom tricepsom (r = 0,29; p = 0,003) i subskapularnim naborom (r = -0,25; p = 0,003). Koncentracija grelina značajno negativno korelira sa stadijem razvoja puberteta. Koncentracija PYY nije povezana s uhranjenošću, antropometrijskim mjerenjima niti stadijem puberteta. Nakon godinu dana došlo je do značajnog smanjenja grelina, dok se razina PYY nije značajno promijenila. Zaključak: Koncentracija grelina je niža kod djece povećane tjelesne mase i debelih u odnosu na normalno uhranjenu djecu, dok koncentracija PYY nije povezana s uhranjenosti. Nakon godine dana praćenje u fiziološkim uvjetima, došlo je do značajnog pada hormona grelina, dok nije bilo značajne promjene hormona PYY.
Item Type: | Thesis (PhD) | ||||
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Departments: | Izvan medicinskog fakulteta | ||||
Depositing User: | dr.med. Helena Markulin | ||||
University: | Sveučilište u Zagrebu | ||||
Institution: | Medicinski fakultet | ||||
Number of Pages: | 123 | ||||
Status: | Unpublished | ||||
Creators: |
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Date: | 3 November 2016 | ||||
Date Deposited: | 05 Sep 2018 11:08 | ||||
Last Modified: | 05 Sep 2018 11:08 | ||||
Subjects: | / | ||||
Related URLs: | |||||
URI: | http://medlib.mef.hr/id/eprint/2992 |
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