Improvement of overlapping hidradenitis suppurativa and ankylosing spondylitis after the introduction of adalimumab

Bosnić, Dubravka and Žarković, Branimir and Barešić, Marko and Žarković, Maja and Anić, Branimir (2016) Improvement of overlapping hidradenitis suppurativa and ankylosing spondylitis after the introduction of adalimumab. Reumatologia/Rheumatology, 54 (6). pp. 321-325. ISSN 0034-6233

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Abstract

Hidradenitis suppurativa is a chronic inflammatory disorder characterized by occlusion of the follicular pilosebaceous units of the skin. The treatment options are sometimes very limited and unpleasant odor and abundant drainage complicate the disease. Ankylosing spondylitis is a form of seronegative spondyloarthritis with predominantly axial but also peripheral joint involvement. Both of the conditions lower the patient's quality of life and affect everyday activities. We describe a 39-year-old male patient with both diseases treated with different medications with only a modest result. After the initiation of a tumor necrosis factor α (TNF-α) inhibitor (adalimumab) the patient experienced first the musculoskeletal and later on the skin improvement. The introduction of TNF-α inhibitors should be considered early in the treatment of overlapping hidradenitis suppurativa and the spondyloarthritis spectrum of conditions. Available medical data confirm the positive results and beneficial effect on disease course, activity and, most importantly, quality of life.

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