Milošević, Danko and Bilić, Ernest and Batinić, Danica and Poropat, Mirjana and Štern-Padovan, Ranka and Galić, Slobodan and Turudić, Daniel (2014) Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors. BMC Pediatrics, 14. p. 315. ISSN 1471-2431
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Abstract
BACKGROUND: Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. ----- CASE PRESENTATION: We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies. ----- CONCLUSION: Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning.
| Item Type: | Article | ||||||||||||||||
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| Additional Information: | © Milošević et al.; licensee BioMed Central. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0) applies to the data made available in this article, unless otherwise stated. | ||||||||||||||||
| MeSH: | Blood Coagulation Factor Inhibitors/metabolism ; Child ; Factor IX/antagonists & inhibitors ; Factor VIIa/adverse effects ; Hematuria/blood ; Hematuria/drug therapy ; Hemophilia B/blood ; Hemophilia B/drug therapy ; Humans ; Kidney/blood supply ; Male ; Recombinant Proteins/adverse effects ; Thromboembolism/chemically induced | ||||||||||||||||
| Departments: | Katedra za pedijatriju Katedra za radiologiju i opću kliničku onkologiju |
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| Depositing User: | Marijan Šember | ||||||||||||||||
| Status: | Published | ||||||||||||||||
| Creators: |
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| Date: | 17 December 2014 | ||||||||||||||||
| Date Deposited: | 24 Feb 2016 12:17 | ||||||||||||||||
| Last Modified: | 17 Jul 2020 09:52 | ||||||||||||||||
| Subjects: | / | ||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/2498 |
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