Krušlin, Božo and Ulamec, Monika and Tomas, Davor (2015) Prostate cancer stroma: an important factor in cancer growth and progression. Bosnian Journal of Basic Medical Sciences, 15 (2). pp. 1-8. ISSN 1512-8601
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Abstract
Reactive stromal changes that occur in different human cancers might play a role in local tumor spreading and progression. Studies done on various human cancers have shown activated stromal cell phenotypes, modified extracellular matrix (ECM) composition, and increased microvessel density. Furthermore, they exhibit biological markers consistent with stroma at the site of wound repair. In prostate cancer, stroma is composed of fibroblasts, myofibroblasts, endothelial cells and immune cells. Predominant cells in the tumorous stroma are, however, fibroblasts/ myofibroblasts. They are responsible for the synthesis, deposition and remodeling of the ECM. Epithelial tumorous cells, in interaction with stromal cells and with the help of various molecules of ECM, create a microenvironment suitable for cancer cell proliferation, movement, and differentiation. In this review, we discussed the role of different stromal components in prostate cancer as well as their potential prognostic and therapeutic significance.
| Item Type: | Article | ||||||||
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| Additional Information: | © 2015 Krušlin et al.; licensee ABMSFBIH. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ||||||||
| MeSH: | Animals ; Cell Proliferation ; Disease Models, Animal ; Disease Progression ; Dogs ; Extracellular Matrix / pathology ; Humans ; Male ; Mice ; Microvessels / pathology ; Phenotype ; Prostatic Neoplasms / blood supply ; Prostatic Neoplasms / pathology ; Rats ; Stromal Cells / pathology | ||||||||
| Departments: | Katedra za patologiju | ||||||||
| Depositing User: | Marijan Šember | ||||||||
| Status: | Published | ||||||||
| Creators: |
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| Date: | May 2015 | ||||||||
| Date Deposited: | 18 Feb 2016 11:36 | ||||||||
| Last Modified: | 23 Jul 2020 07:46 | ||||||||
| Subjects: | / | ||||||||
| Related URLs: | |||||||||
| URI: | http://medlib.mef.hr/id/eprint/2461 |
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