Potentially malignant oral disorders and high-risk habits in liver cirrhosis and lung cancer patients

Salarić, Ivan and Povrzanović, Ivo and Brajdić, Davor and Lukšić, Ivica and Macan, Darko (2014) Potentially malignant oral disorders and high-risk habits in liver cirrhosis and lung cancer patients. Oral Diseases, 21 (3). pp. 373-377. ISSN 1354-523X

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Abstract

OBJECTIVES: To analyze the role of smoking, drinking, and their synergistic effect in the occurrence of potentially malignant oral disorders (PMOD). ----- SUBJECTS AND METHODS: We examined three groups: 50 patients with lung cancer, 50 patients with liver cirrhosis, and 50 patients with clear medical history. Scores were developed for drinking, smoking, drinking & smoking, and PMOD. ----- RESULTS: All four scores were the lowest in the control group. The lung cancer group showed the highest Smoking, Alcohol & Smoking and Lesions score, while the liver cirrhosis group had the Alcohol score the highest. Compared with the control group, lung cancer group is more likely to develop a PMOD than the liver cirrhosis group (OR = 12.31/OR = 6.71). Statistical significance between the groups was found in the Lesions score (χ(2) = 15.34; P = 0.001). ----- CONCLUSIONS: The patients with lung cancer and liver cirrhosis represent a high-risk group for PMOD. Patients with lung cancer and liver cirrhosis have never, to our knowledge, been categorized as high-risk patients for PMOD. After diagnosed, patients with lung cancer and liver cirrhosis should have a routine oral cavity examination, as they present a high-risk group for PMOD and oral cancer.

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