Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma

Grbeša, Ivana and Ivkić, Mirko and Pegan, Boris and Gall-Trošelj, Koraljka (2006) Loss of imprinting and promoter usage of the IGF2 in laryngeal squamous cell carcinoma. Cancer Letters, 238 (2). pp. 224-229. ISSN 0304-3835

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Official URL: https://doi.org/10.1016/j.canlet.2005.07.003

Abstract

The gene for insulin-like growth factor two, IGF2 is maternally imprinted. Fifteen heterozygous samples were analyzed for the IGF2 imprinting status and promoter usage. IGF2 LOI was detected in four non-tumorous tissues and in six laryngeal squamous cell carcinoma (LSCC) tumors. There was no clear pattern of specific promoter activity in LSCC tumors and the adjacent normal tissues. P1 promoter usage was active in eight LSCCs, among them four with LOI. As it was activated in four tumors with maintenance of imprinting (MOI) and four non-tumors, we concluded that P1 promoter is not exclusively connected with IGF2 LOI in LSCC.

Item Type:

Article

MeSH:

Carcinoma, Squamous Cell - genetics ; Genomic Imprinting ; Insulin-Like Growth Factor II - genetics ; Laryngeal Neoplasms - genetics ; Promoter Regions (Genetics) ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged

Departments:

Katedra za otorinoloringologiju s audiologijom i fonijatrijom

Depositing User:

Lea Škorić

Status:

Published

Creators: