Lifestyle habits and the risk of head and neck cancer in Zagreb region [Životne navike i rizik za rak glave i vrata u Zagrebačkoj regiji]

Znaor, Ariana and Virag, Mišo and Znaor, Tin and Manojlović, Spomenka and Kušec, Rajko (2011) Lifestyle habits and the risk of head and neck cancer in Zagreb region [Životne navike i rizik za rak glave i vrata u Zagrebačkoj regiji]. Collegium Antropologicum, 35 (4). pp. 1125-1128. ISSN 0350-6134

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Abstract

In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck cancer in 15 centres in 11 European countries, Croatia included. The Alcohol-related Cancers and Genetic Susceptibility in Europe (ARCAGE) study database with approximately 2500 case-control pairs is currently the largest head and neck cancer patients database in Europe. The aim of the present study was to estimate the risk of smoking and alcohol consumption in head and neck cancer patients from Zagreb region recruited in scope of the ARCAGE study. The cases (45 males, 9 females) and the controls (37 males, 9 females) were recruited from University Hospital Dubrava and Merkur University Hospital. A blood sample and a lifestyle questionnaire were collected from all study subjects. Data were analysed by logistic regression analysis. The distribution of cases was: 43 oral, 9 pharyngeal and 2 laryngeal cancer cases. Ever-smokers had a 4-fold higher cancer risk (adjusted OR 4.3 (CI 1.20-15.4)) compared to never-smokers. The adjusted odds ratio for alcohol consumption more than once a week was 4.1 (CI 1.5-11.2). The results are in keeping with previously published data from other countries.

Abstract in Croatian

Međunarodna agencija za istraživanje raka 2002. godine započela je multicentrično slučaj-kontrola istraživanje raka glave i vrata u 15 centara u 11 europskih država uključujući Hrvatsku. Baza podataka istraživanja ARCAGE s oko 2500 parova slučaj-kontrola trenutno je najveća baza podataka o bolesnicima od raka glave i vrata u Europi. Cilj ovog istra- živanja bio je procijeniti rizik pušenja i konzumacije alkohola u bolesnika od raka glave i vrata iz zagrebačke regije regrutiranih u okviru istraživanja ARCAGE. Slučajevi (45 muškaraca i 9 žena) i kontrole (37 muškaraca, 9 žena) regrutirani su iz Klinčke bolnice Dubrava i Kliničke bolnice Merkur. Od svih ispitanika prikupljen je uzorak krvi i anketni upitnik. Podaci su analizirani logističkom regresijom. Raspodjela slučajeva bila je: 43 slučaja raka usne šupljine, 9 ždrijela i 2 grkljana. Pušači su imali četverostruko veći rizik za rak glave i vrata od nepušača (OR 4,3 (CI 1,20–15,4)). Prilagođeni odnos šansi za konzumaciju alkohola više od jednom tjedno bio je 4,1 (CI 1,5–11,2). Rezultati su u skladu s prethodno objavljenim podacima iz drugih zemalja.

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