Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma

Jakovljević, Gordana and Nakić, Melita and Rogošić, Srđan and Kardum-Skelin, Ika and Mrsić-Davidović, Sanja and Zadro, Renata and Krušlin, Božo (2010) Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma. Pediatric Blood & Cancer, 54 (4). pp. 606-609. ISSN 1545-5009

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Official URL: https://doi.org/10.1002/pbc.22365

Abstract

We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and EWS/FLI1 transcript. After finding lymphoblasts in peripheral blood, the diagnosis of acute lymphoblastic leukemia was established. This necessitated further analysis of the subcutaneous tumor. The tissue was positive for immature B-cell markers and an immunoglobulin heavy chain gene rearrangement, which confirmed the final diagnosis of common type acute lymphoblastic leukemia with bulk extramedullary disease. The patient was treated with chemotherapy and was in remission 30 months after the diagnosis.

Item Type:

Article

MeSH:

Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Child, Preschool ; Chromosomes, Human, Pair 22/genetics ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Oncogene Proteins, Fusion/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Ewing's/diagnosis ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/drug therapy ; Soft Tissue Neoplasms/genetics ; Transcription Factors/genetics

Departments:

Katedra za patologiju

Depositing User:

Marijan Šember

Status:

Published

Creators:

Creators	Email
Jakovljević, Gordana	UNSPECIFIED
Nakić, Melita	UNSPECIFIED
Rogošić, Srđan	UNSPECIFIED
Kardum-Skelin, Ika	UNSPECIFIED
Mrsić-Davidović, Sanja	UNSPECIFIED
Zadro, Renata	UNSPECIFIED
Krušlin, Božo	UNSPECIFIED

Date:

April 2010

Date Deposited:

02 Dec 2011 10:42

Last Modified:

26 Mar 2020 14:19

Subjects:

Related URLs:

Publisher

URI:

http://medlib.mef.hr/id/eprint/1410

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