Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide

Štefulj, Jasminka and Mokrović, Gordana and Hranilović, Dubravka and Bordukalo-Nikšić, Tatjana and Bakula, Mirko and Kubat, Milovan and Jernej, Branimir (2010) Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide. Psychiatry Research, 186 (2-3). pp. 446-447. ISSN 0165-1781

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The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion.

Item Type: Article
MeSH: Chi-Square Distribution ; Cohort Studies ; Croatia / epidemiology ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Polymorphism, Genetic / genetics ; Promoter Regions, Genetic / genetics ; Self-Injurious Behavior / genetics ; Suicide ; Tryptophan Hydroxylase / genetics
Departments: Hrvatski institut za istraživanje mozga
Katedra za sudsku medicinu
Depositing User: Marijan Šember
Status: Published
Štefulj, JasminkaUNSPECIFIED
Mokrović, GordanaUNSPECIFIED
Hranilović, DubravkaUNSPECIFIED
Bordukalo-Nikšić, TatjanaUNSPECIFIED
Jernej, BranimirUNSPECIFIED
Date: 30 April 2010
Date Deposited: 27 Oct 2010
Last Modified: 14 Jul 2020 09:25
Subjects: /
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