Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes

Grčević, Danka and Kušec, Rajko and Kovačić, Nataša and Lukić, Anita and Lukić, Ivan Krešimir and Ivčević, Sanja and Nemet, Damir and Serventi Seiwerth, Ranka and Kolonić Ostojić, Slobodanka and Croucher, Peter I and Marušić, Ana (2009) Bone morphogenetic proteins and receptors are over-expressed in bone-marrow cells of multiple myeloma patients and support myeloma cells by inducing ID genes. Leukemia Research, [Epub . ISSN 0145-2126

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    English abstract

    We assessed the expression pattern and clinical relevance of BMPs and related molecules in multiple myeloma (MM). MM bone-marrow samples (n=32) had increased BMP4, BMP6, ACVR1 and ACVR2A, and decreased NOG expression compared with controls (n=15), with BMP6 having the highest sensitivity/specificity. Within MM bone-marrow, the source of BMPs was mainly CD138(+) plasma-cell population, and BMP6 and ACVR1 expression correlated with plasma-cell percentage. Using myeloma cell lines NCI H929 and Thiel we showed that BMPs induced ID1, ID2 and IL6, and suppressed CDKN1A and BAX gene expression, and BAX protein expression. Finally, BMPs partially protected myeloma cells from bortezomib- and TRAIL-induced apoptosis. We concluded that BMPs may be involved in MM pathophysiology and serve as myeloma cell biomarkers.

    Item Type: Article
    Divisions: Katedra za fiziologiju i imunologiju
    Katedra za internu medicinu
    Katedra za anatomiju i kliničku anatomiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Grčević, Danka
    Kušec, Rajko
    Kovačić, Nataša
    Lukić, Anita
    Lukić, Ivan Krešimir
    Ivčević, Sanja
    Nemet, Damir
    Serventi Seiwerth, Ranka
    Kolonić Ostojić, Slobodanka
    Croucher, Peter I
    Marušić, Ana
    Date: 17 November 2009
    Date Deposited: 02 Feb 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/706

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