Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Nucleolar protein 1 (Nol1) expression in the mouse brain

Mitrečić, Dinko and Malnar, Tajana and Gajović, Srećko (2008) Nucleolar protein 1 (Nol1) expression in the mouse brain. Collegium antropologicum, 32 (Suppl.). pp. 123-126. ISSN 0350-6134 (Print)

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    Croatian abstract

    Bjelančevina jezgrice 1 (Nucleolar protein 1, Nol1) je gen izražen u stanicama koje se umnažaju, te mu izražaj ovisi o fazi staničnog ciklusa. Kako bismo testirali hipotezu da je Nol1 potencijalni biljeg stanica u diobi u mozgu miša (živčane matične stanice), analizirali smo izražaj Nol1 u mozgu miša kojem je Nol1 preinačen postupkom genske zamke. Ekspresija Nol1 je nađena u hipokampusu, njušnom bulbusu, te u kori velikog i malog mozga. Ovaj nalaz je ukazao da Nol1 nije izražen samo u stanicama koje se dijele, već i u diferenciranim živčanim stanicama. Pretpostavljeno je kako Nol1 ima ulogu u sintezi ribosoma i bjelančevina u stanicama živčanog sustava.

    English abstract

    Nucleolar protein 1 (Nol1) is a cell cycle dependent gene highly expressed in proliferating tissues. In order to test whether Nol1 could be used as a marker of dividing neural stem cells within mouse brain, Nol1 expression was analyzed using mouse carrying a gene trap modification of Nol1 gene. High Nol1 expression was found within the hippocampus, olfactory bulb, cerebral and cerebellar cortex. Nol1 was expressed not only in the dividing cells within the brain, but as well in the postmitotic neurons. This suggested a general role of Nol1 in assembling of ribosomes in cells with high protein production.

    Item Type: Article
    MeSH: Brain - metabolism ; Nuclear Proteins - genetics - isolation & purification - metabolism ; Stem Cells - metabolism ; Animals ; Mice
    Divisions: Katedra za histologiju i embriologiju
    Hrvatski institut za istraživanje mozga
    Depositing User: Boris Čičovački
    Status: Published
    Creators:
    CreatorsEmail
    Mitrečić, Dinko
    Malnar, Tajana
    Gajović, Srećko
    Date: January 2008
    Date Deposited: 03 Oct 2008
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/398

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