Epigenetics and testicular germ cell tumors

Buljubašić, Robert and Buljubašić, Maja and Bojanac, Ana Katušić and Ulamec, Monika and Vlahović, Maja and Ježek, Davor and Bulić-Jakuš, Floriana and Sinčić, Nino (2018) Epigenetics and testicular germ cell tumors. Gene, 661. pp. 22-33. ISSN 0378-1119

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Official URL: https://doi.org/10.1016/j.gene.2018.03.072

Abstract

Malignant testicular germ cell tumors (TGCTs) are the most frequent testicular cancers in Caucasian males, developing at the most productive age of man. We are briefly reviewing TGCT-tumorigenesis with an emphasis on epigenetics. Epigenetic mechanisms such as DNA methylation and histone modifications together with RNA interference that all change gene expression are driving early spermatogenesis. Deregulation of normal development might lead to a testicular germ cell neoplasia in situ (GCNIS), from which TGCTs originate. The breakthrough epigenetic research, both in normal development and TGCT tumorigenesis, has been going on to find better biomarkers and therapy for this type of tumors.

Item Type:

Article

Additional Information:

MeSH:

DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Epigenomics/methods ; Humans ; Male ; Neoplasms, Germ Cell and Embryonal/genetics ; Testicular Neoplasms/genetics

Departments:

Katedra za histologiju i embriologiju
Katedra za medicinsku biologiju

Depositing User:

Kristina Berketa

Status:

Published

Creators:

Creators	Email
Buljubašić, Robert	UNSPECIFIED
Buljubašić, Maja	UNSPECIFIED
Bojanac, Ana Katušić	UNSPECIFIED
Ulamec, Monika	UNSPECIFIED
Vlahović, Maja	UNSPECIFIED
Ježek, Davor	UNSPECIFIED
Bulić-Jakuš, Floriana	UNSPECIFIED
Sinčić, Nino	UNSPECIFIED

Date:

30 June 2018

Date Deposited:

30 Sep 2019 10:05

Last Modified:

25 Aug 2020 07:19

Subjects:

Related URLs:

Publisher

URI:

http://medlib.mef.hr/id/eprint/3411

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