HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse

Burek Kamenarić, Marija and Maskalan, Marija and Grubić, Zorana and Mikulić, Mirta and Serventi Seiwerth, Ranka and Duraković, Nadira and Vrhovac, Radovan and Štingl Janković, Katarina and Žunec, Renata (2017) HLA-DPB1 matching in unrelated hematopoietic stem cell transplantation program contributes to a higher incidence of disease relapse. Human Immunology, 78 (11-12). pp. 665-671. ISSN 0198-8859

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The impact of patient/donor matching for HLA-A, -B, -C, -DRB1 and -DQB1 genes in hematopoietic stem cell transplantation (HSCT) is well-recognized, but typing for additional genes, such as HLA-DPB1, is still controversial. Based on defined T-cell epitope (TCE) groups, all HLA-DPB1 mismatches can be classified as permissive or non-permissive. In this retrospective study we analysed 82 patient-matched unrelated donor (MUD) pairs who underwent HSCT, and explored the impact of HLA-DPB1 matches, permissive and non-permissive mismatches on transplantation outcomes. Patient-MUD pairs matched for HLA-DPB1 alleles in univariate analysis were associated with a significantly higher incidence of disease relapse compared to pairs who were permissive/non-permissive HLA-DPB1 mismatched according to the TCE3 and TCE4 algorithms (P=0.025 and P=0.026, respectively), although the significance was lost in multivariate analysis. The analysis did not reveal any significant influence of HLA-DPB1 alleles on overall survival (OS), non-relapse mortality (NRM) or graft-versus-host disease (GvHD) incidence. In conclusion, our study presents evidence that HLA-DPB1 matching influenced the relapse rate in patients after HSCT so the HLA-DPB1 alleles should be implemented in the MUD search algorithm as a transplantation determinant.

Item Type: Article
MeSH: Adolescent ; Adult ; Epitopes, T-Lymphocyte / metabolism ; Female ; Genotype ; Graft Survival ; Graft vs Host Disease / epidemiology ; Graft vs Host Disease / genetics ; Graft vs Host Disease / mortality ; HLA-DP beta-Chains / genetics ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; Histocompatibility Testing ; Humans ; Incidence ; Male ; Middle Aged ; Recurrence ; Retrospective Studies ; Risk ; Survival Analysis ; Young Adult
Departments: Katedra za internu medicinu
Depositing User: Martina Žužak
Status: Published
Burek Kamenarić, MarijaUNSPECIFIED
Maskalan, MarijaUNSPECIFIED
Serventi Seiwerth, RankaUNSPECIFIED
Duraković, NadiraUNSPECIFIED
Vrhovac, RadovanUNSPECIFIED
Štingl Janković, KatarinaUNSPECIFIED
Date: November 2017
Date Deposited: 04 Feb 2019 10:36
Last Modified: 17 Aug 2020 09:12
Related URLs:
URI: http://medlib.mef.hr/id/eprint/2920

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