Bilić, Ranko and Šimić, Petra and Jelić, Mislav and Štern-Padovan, Ranka and Dodig, Damir and Pompe van Meerdervoort, Hjalmar and Martinović, Snježana and Ivanković, Davor and Pećina, Marko and Vukičević, Slobodan (2006) Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. International Orthopaedics , 30 (2). pp. 128-134. ISSN 0341-2695 (Print) 1432-5195 (Electronic)
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English abstract
We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.
| Item Type: | Article | ||||||||||||||||||||||
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| MeSH: | Bone Morphogenetic Proteins - pharmacology ; Fracture Healing - drug effects ; Fractures , Ununited - drug therapy - radiography - radionuclide imaging - surgery ; Ilium - transplantation ; Scaphoid Bone - injuries - radiography - radionuclide imaging - surgery ; Transforming Growth Factor beta - pharmacology ; Adolescent ; Adult ; Analysis of Variance ; Female ; Humans ; Male ; Tomography , Spiral Computed | ||||||||||||||||||||||
| Divisions: | Katedra za ortopediju Katedra za internu medicinu Katedra za anatomiju i kliničku anatomiju Katedra za radiologiju i opću kliničku onkologiju Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku | ||||||||||||||||||||||
| Depositing User: | Lea Škorić | ||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||
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| Date: | April 2006 | ||||||||||||||||||||||
| Date Deposited: | 04 Dec 2006 | ||||||||||||||||||||||
| Last Modified: | 23 Sep 2011 18:09 | ||||||||||||||||||||||
| Subjects: | / | ||||||||||||||||||||||
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| URI: | http://medlib.mef.hr/id/eprint/151 |
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