Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis

Bilić, Ranko and Šimić, Petra and Jelić, Mislav and Štern-Padovan, Ranka and Dodig, Damir and Pompe van Meerdervoort, Hjalmar and Martinović, Snježana and Ivanković, Davor and Pećina, Marko and Vukičević, Slobodan (2006) Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. International Orthopaedics , 30 (2). pp. 128-134. ISSN 0341-2695 (Print) 1432-5195 (Electronic)

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Abstract

We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.

Item Type: Article
MeSH: Bone Morphogenetic Proteins - pharmacology ; Fracture Healing - drug effects ; Fractures , Ununited - drug therapy - radiography - radionuclide imaging - surgery ; Ilium - transplantation ; Scaphoid Bone - injuries - radiography - radionuclide imaging - surgery ; Transforming Growth Factor beta - pharmacology ; Adolescent ; Adult ; Analysis of Variance ; Female ; Humans ; Male ; Tomography , Spiral Computed
Departments: Katedra za ortopediju
Katedra za internu medicinu
Katedra za anatomiju i kliničku anatomiju
Katedra za radiologiju i opću kliničku onkologiju
Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
Depositing User: Lea Škorić
Status: Published
Creators:
CreatorsEmail
Bilić, RankoUNSPECIFIED
Šimić, PetraUNSPECIFIED
Jelić, MislavUNSPECIFIED
Štern-Padovan, RankaUNSPECIFIED
Dodig, DamirUNSPECIFIED
Pompe van Meerdervoort, Hjalmar UNSPECIFIED
Martinović, SnježanaUNSPECIFIED
Ivanković, DavorUNSPECIFIED
Pećina, MarkoUNSPECIFIED
Vukičević, SlobodanUNSPECIFIED
Date: April 2006
Date Deposited: 04 Dec 2006
Last Modified: 23 Sep 2011 16:09
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/151

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