Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis

Bilić, Ranko and Šimić, Petra and Jelić, Mislav and Štern-Padovan, Ranka and Dodig, Damir and Pompe van Meerdervoort, Hjalmar and Martinović, Snježana and Ivanković, Davor and Pećina, Marko and Vukičević, Slobodan (2006) Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. International Orthopaedics , 30 (2). pp. 128-134. ISSN 0341-2695 (Print) 1432-5195 (Electronic)

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    English abstract

    We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.

    Item Type: Article
    MeSH: Bone Morphogenetic Proteins - pharmacology ; Fracture Healing - drug effects ; Fractures , Ununited - drug therapy - radiography - radionuclide imaging - surgery ; Ilium - transplantation ; Scaphoid Bone - injuries - radiography - radionuclide imaging - surgery ; Transforming Growth Factor beta - pharmacology ; Adolescent ; Adult ; Analysis of Variance ; Female ; Humans ; Male ; Tomography , Spiral Computed
    Divisions: Katedra za ortopediju
    Katedra za internu medicinu
    Katedra za anatomiju i kliničku anatomiju
    Katedra za radiologiju i opću kliničku onkologiju
    Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
    Depositing User: Lea Škorić
    Status: Published
    Bilić, Ranko
    Šimić, Petra
    Jelić, Mislav
    Štern-Padovan, Ranka
    Dodig, Damir
    Pompe van Meerdervoort, Hjalmar
    Martinović, Snježana
    Ivanković, Davor
    Pećina, Marko
    Vukičević, Slobodan
    Date: April 2006
    Date Deposited: 04 Dec 2006
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
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