Bojanić, Ines and Dubravčić, Klara and Batinić, Drago and Golubić Ćepulić, Branka and Mazić, Sanja and Hren, Darko and Nemet, Damir and Labar, Boris (2011) Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times. Transfusion and Apheresis Science, 44 (2). pp. 139-47. ISSN 1473-0502
Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required.
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