Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times

Bojanić, Ines and Dubravčić, Klara and Batinić, Drago and Golubić Ćepulić, Branka and Mazić, Sanja and Hren, Darko and Nemet, Damir and Labar, Boris (2011) Large volume leukapheresis: Efficacy and safety of processing patient's total blood volume six times. Transfusion and Apheresis Science, 44 (2). pp. 139-47. ISSN 1473-0502

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Abstract

Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required.

Item Type: Article
Departments: Katedra za fiziologiju i imunologiju
Katedra za internu medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Bojanić, InesUNSPECIFIED
Dubravčić, KlaraUNSPECIFIED
Batinić, DragoUNSPECIFIED
Golubić Ćepulić, BrankaUNSPECIFIED
Mazić, SanjaUNSPECIFIED
Hren, DarkoUNSPECIFIED
Nemet, DamirUNSPECIFIED
Labar, BorisUNSPECIFIED
Date: April 2011
Date Deposited: 20 Apr 2011
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/981

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