Bojanić, Ines and Dubravčić, Klara and Batinić, Drago and Golubić Ćepulić, Branka and Mazić, Sanja and Hren, Darko and Nemet, Damir and Labar, Boris (2011) Large volume leukapheresis: efficacy and safety of processing patient's total blood volume six times. Transfusion and Apheresis Science, 44 (2). pp. 139-147. ISSN 1473-0502
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Abstract
Large-volume leukapheresis (LVL) differs from standard leukapheresis by increased blood flow and an altered anticoagulation regimen. An open issue is to what degree a further increase in processed blood volume is reasonable in terms of higher yields and safety. In 30 LVL performed in patients with hematologic malignancies, 6 total blood volumes were processed. LVL resulted in a higher CD34+ cell yield without a change in graft quality. Although a marked platelet decrease can be expected, LVL is safe and can be recommended as the standard procedure for patients who mobilize low numbers of CD34+ cells and when high number of CD34+ cells are required.
| Item Type: | Article | ||||||||||||||||||
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| MeSH: | Adult ; Antigens, CD34 / biosynthesis ; Blood Platelets / metabolism ; Electrolytes ; Female ; Hematologic Neoplasms / therapy ; Hematopoietic Stem Cell Mobilization / methods ; Humans ; Kinetics ; Leukapheresis / methods ; Leukocytes / cytology ; Leukocytes, Mononuclear / cytology ; Male ; Middle Aged ; Safety | ||||||||||||||||||
| Departments: | Katedra za fiziologiju i imunologiju Katedra za internu medicinu |
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| Depositing User: | Marijan Šember | ||||||||||||||||||
| Status: | Published | ||||||||||||||||||
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| Date: | April 2011 | ||||||||||||||||||
| Date Deposited: | 20 Apr 2011 | ||||||||||||||||||
| Last Modified: | 27 Apr 2020 12:00 | ||||||||||||||||||
| Subjects: | / | ||||||||||||||||||
| Related URLs: | |||||||||||||||||||
| URI: | http://medlib.mef.hr/id/eprint/981 |
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