Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder

Radonić, Elizabeta and Radoš, Marko and Kalember, Petra and Bajs-Janović, Maja and Folnegović-Šmalc, Vera and Henigsberg, Neven (2011) Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder. Collegium Antropologicum, 35 (Suppl.). pp. 249-52. ISSN 0353-3735

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Abstract

The reduction of hippocampal volume was frequently reported in schizophrenia, but not in bipolar disorder. This volume reduction is associated with clinical features of schizophrenia, in particular with working and verbal memory impairments. Schizoaffective disorder, as a specific disorder sharing clinical features of both schizophrenia and bipolar disorder is rarely analyzed as a separate disorder in neurobiological studies. The aim of this study was to compare hippocampal volumes in separate groups of patients with schizophrenia, schizoaffective and bipolar disorder. Hippocampal volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There were no significant differences in hippocampal volume between bipolar disorder and control group. Hippocampal volume was statistically significantly reduced in the group of patients with schizophrenia and schizoaffective disorder, compared to either bipolar disorder or control group, thus supporting the hypothesis that hippocampal volume reduction could be considered as a possible neurobiological basis for clinical aspects of schizophrenia and schizoaffective disorder associated with working and verbal memory impairment.

Abstract in Croatian

USPOREDBA VOLUMENA HIPOKAMPUSA U SHIZOFRENIJI, SHIZOAFEKTIVNOM I BIPOLARNOM POREMEĆAJU ----- Smanjenje volumena hipokampusa čest je nalaz u shizofreniji, ali ne i u bipolarnom poremećaju. Ovo smanjenje volumena povezano je s kliničkim obilježjima shizofrenije, posebice oštećenjima radnog i verbalnog pamćenja. Shizoafektivni poremećaj, specifični poremećaj u kojem se ispoljavaju klinička obilježja i shizofrenije i bipolarnog poremećaja, rijetko se analizira kao zasebni poremećaj u neurobiološkim istraživanjima uopće. Cilj ovog istraživanja bio je usporediti volumen hipokampusa u zasebnim skupinama pacijenata sa shizofrenijom, shizoafektivnim i bipolarnim poremećajem. Za mjerenje volumena hipokampusa rabljena je metoda oslikavanja mozga magnetskom rezonancijom visoke rezolucije na 60 ispitanika, po 15 u svakoj skupini oboljelih kao i u skupini duševno zdravih dobrovoljaca (kontrolna skupina). Nema statistički značajnih razlika u volumenu hipokampusa između pacijenata s bipolarnim poremećajem i kontrolne skupine. Volumen hipokampusa statistički je značajno smanjen u skupinama pacijenata sa shizofrenijom odnosno sa shizoafektivnim poremećajem, o odnosu na skupinu s bipolarnim poremećajem kao i na kontrolnu skupinu. Ovaj rezultat podržava pretpostavku da smanjenje volumena hipokampusa može predstavljati neurobiološku podlogu kliničkih obilježja shizofrenije i shizoafektivnog poremećaja povezanih s oštećenjima radnog i verbalnog pamćenja.

Item Type: Article
Departments: Katedra za psihijatriju i psihološku medicinu
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Radonić, ElizabetaUNSPECIFIED
Radoš, MarkoUNSPECIFIED
Kalember, PetraUNSPECIFIED
Bajs-Janović, MajaUNSPECIFIED
Folnegović-Šmalc, VeraUNSPECIFIED
Henigsberg, NevenUNSPECIFIED
Date: January 2011
Date Deposited: 21 Mar 2011
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/971

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