Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder

Radonić, Elizabeta and Radoš, Marko and Kalember, Petra and Bajs-Janović, Maja and Folnegović-Šmalc, Vera and Henigsberg, Neven (2011) Comparison of hippocampal volumes in schizophrenia, schizoaffective and bipolar disorder. Collegium Antropologicum, 35 (Suppl.). pp. 249-52. ISSN 0353-3735

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    Croatian abstract

    USPOREDBA VOLUMENA HIPOKAMPUSA U SHIZOFRENIJI, SHIZOAFEKTIVNOM I BIPOLARNOM POREMEĆAJU ----- Smanjenje volumena hipokampusa čest je nalaz u shizofreniji, ali ne i u bipolarnom poremećaju. Ovo smanjenje volumena povezano je s kliničkim obilježjima shizofrenije, posebice oštećenjima radnog i verbalnog pamćenja. Shizoafektivni poremećaj, specifični poremećaj u kojem se ispoljavaju klinička obilježja i shizofrenije i bipolarnog poremećaja, rijetko se analizira kao zasebni poremećaj u neurobiološkim istraživanjima uopće. Cilj ovog istraživanja bio je usporediti volumen hipokampusa u zasebnim skupinama pacijenata sa shizofrenijom, shizoafektivnim i bipolarnim poremećajem. Za mjerenje volumena hipokampusa rabljena je metoda oslikavanja mozga magnetskom rezonancijom visoke rezolucije na 60 ispitanika, po 15 u svakoj skupini oboljelih kao i u skupini duševno zdravih dobrovoljaca (kontrolna skupina). Nema statistički značajnih razlika u volumenu hipokampusa između pacijenata s bipolarnim poremećajem i kontrolne skupine. Volumen hipokampusa statistički je značajno smanjen u skupinama pacijenata sa shizofrenijom odnosno sa shizoafektivnim poremećajem, o odnosu na skupinu s bipolarnim poremećajem kao i na kontrolnu skupinu. Ovaj rezultat podržava pretpostavku da smanjenje volumena hipokampusa može predstavljati neurobiološku podlogu kliničkih obilježja shizofrenije i shizoafektivnog poremećaja povezanih s oštećenjima radnog i verbalnog pamćenja.

    English abstract

    The reduction of hippocampal volume was frequently reported in schizophrenia, but not in bipolar disorder. This volume reduction is associated with clinical features of schizophrenia, in particular with working and verbal memory impairments. Schizoaffective disorder, as a specific disorder sharing clinical features of both schizophrenia and bipolar disorder is rarely analyzed as a separate disorder in neurobiological studies. The aim of this study was to compare hippocampal volumes in separate groups of patients with schizophrenia, schizoaffective and bipolar disorder. Hippocampal volumes were estimated using high resolution magnetic resonance imaging in 60 subjects, 15 subjects in each patient and one healthy volunteer (control) group. There were no significant differences in hippocampal volume between bipolar disorder and control group. Hippocampal volume was statistically significantly reduced in the group of patients with schizophrenia and schizoaffective disorder, compared to either bipolar disorder or control group, thus supporting the hypothesis that hippocampal volume reduction could be considered as a possible neurobiological basis for clinical aspects of schizophrenia and schizoaffective disorder associated with working and verbal memory impairment.

    Item Type: Article
    Divisions: Katedra za psihijatriju i psihološku medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Radonić, Elizabeta
    Radoš, Marko
    Kalember, Petra
    Bajs-Janović, Maja
    Folnegović-Šmalc, Vera
    Henigsberg, Neven
    Date: January 2011
    Date Deposited: 21 Mar 2011
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/971

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