Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Intracranial tumors in adult population of the Varazdin County (Croatia) 1996-2004: a population-based retrospective incidence study

Dobec-Meić, Biserka and Pikija, Slaven and Cvetko, Danijel and Trkulja, Vladimir and Pažanin, Leo and Kudelić, Nenad and Rotim, Krešimir and Pavliček, Ivan and Kostanjevec, Ruža (2006) Intracranial tumors in adult population of the Varazdin County (Croatia) 1996-2004: a population-based retrospective incidence study. Journal of Neuro-Oncology, 78 (3). pp. 303-310. ISSN 0167-594X (Print) 1573-7373 (Electronic)

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    English abstract

    Aim: To estimate the incidence of intracranial tumors in the adult population of the Varazdin County, Croatia, for the 1996-2004 period. - - - - - Methods: Setting: Varazdin County General Hospital and four university hospitals in Zagreb, the capital of Croatia. Study period: January 1, 1996 to December 31, 2004. Incident patients: county residents admitted for newly diagnosed intracranial tumors according to the WHO diagnostic criteria. Demographic data were extracted from the 2001 Croatian census. Incidence rates (IRs) per 100,000 person-years (p-y) and annual IRs (per 100,000 persons) were determined and compared as incidence rate ratios (IRRs) with 95% CI. - - - - - Results: For primary intracranial tumors (PITs), IR was 12.1/100,000 p-y (95% CI: 10.3-14.2), comparable in men and women. The highest incidence was recorded for glioblastoma (IR 4.8, 3.7-6.2) and meningioma (IR 3.1, 2.2-4.2). The incidence of PIT was somewhat greater than that of metastatic tumors (IRR 1.58, 95% CI: 1.22-2.05, P < 0.001). Metastatic tumors were more frequent in men than in women, especially metastatic lung tumors (IRR 6.08, 2.32-20.16, P < 0.001). IRs of all PIT taken together, neuroepithelial tumors cumulatively, nonepithelial tumors cumulatively, glioblastoma and meningioma were higher in the population aged >= 40 vs. population aged <= 39 (all IRRs with 95% CI greater than 1, P < 0.05 or < 0.001), comparable in men and women. Women were somewhat older than men at the time of diagnosis of PIT: median difference -6 years (95.1% CI: -10 to -1, P < 0.05). Annual IRs for all these tumor categories showed increasing trends over the study period. - - - - - Conclusion: Overall, there was an increasing trend in the incidence of primary intracranial tumors in the Varazdin County. Data did not allow estimation for most of the specific tumor types.

    Item Type: Article
    MeSH: Brain Neoplasms - classification - epidemiology ; Glioblastoma - epidemiology ; Meningioma - epidemiology ; Adult ; Age Distribution ; Aged ; Cohort Studies ; Confidence Intervals ; Croatia - epidemiology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Retrospective Studies ; Sex Distribution ; Statistics, Nonparametric
    Divisions: Katedra za farmakologiju
    Depositing User: Slaven Semper
    Status: Published
    Creators:
    CreatorsEmail
    Dobec-Meić, Biserka
    Pikija, Slaven
    Cvetko, Danijel
    Trkulja, Vladimir
    Pažanin, Leo
    Kudelić, Nenad
    Rotim, Krešimir
    Pavliček, Ivan
    Kostanjevec, Ruža
    Date: July 2006
    Date Deposited: 11 Dec 2006
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/95

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