Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Metabolic syndrome and serum homocysteine in patients with bipolar disorder and schizophrenia treated with SGA

Vuksan-Ćusa, Bjanka and Jakovljević, Miro and Šagud, Marina and Mihaljević Peleš, Alma and Marčinko, Darko and Topić, Radmila and Mihaljević, Sanea and Sertić, Jadranka (2011) Metabolic syndrome and serum homocysteine in patients with bipolar disorder and schizophrenia treated with SGA. Psychiatry Research, [Epub . ISSN 0165-1781

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    English abstract

    There is accumulating evidence for an increased prevalence of metabolic syndrome (MetS) in bipolar patients, which is comparable to the prevalence of MetS in patients with schizophrenia. Hyperhomocysteinaemia has emerged as an independent and graded risk factor for the development of cardiovascular disease (CVD), which is, at the same time, the primary clinical outcome of MetS. The aim of this study was to ascertain if the presence of MetS was associated with hyperhomocysteinaemia in patients with bipolar disorder (N=36) and schizophrenia (N=46) treated with second-generation antipsychotics (SGA). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria and the cut-off point for hyperhomocysteinaemia was set up at 15μmoll(-1). Results of the study indicated that the presence of the MetS is statistically significantly associated with the elevated serum homocysteine in all participants. As hyperhomocysteinaemia has emerged as an independent risk factor for psychiatric disorder and CVD, it could be useful to include fasting homocysteine serum determination in the diagnostic panels of psychiatric patients to obtain a better assessment of their metabolic risk profile.

    Item Type: Article
    Divisions: Katedra za medicinsku kemiju, biokemiju i kliničku kemiju
    Katedra za psihijatriju i psihološku medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Vuksan-Ćusa, Bjanka
    Jakovljević, Miro
    Šagud, Marina
    Mihaljević Peleš, Alma
    Marčinko, Darko
    Topić, Radmila
    Mihaljević, Sanea
    Sertić, Jadranka
    Date: 06 January 2011
    Date Deposited: 25 Feb 2011
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/949

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