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The possibilities and limitations of direct digital radiography, ultrasound and computed tomography in diagnosing pleural mesotelioma

Popić Ramač, Jelena and Hebrang, Andrija and Ivanovi-Herceg, Zlata and Vidjak, Vinko and Brnić, Zoran and Novačić, Karlo and Fistonić, Ivan (2010) The possibilities and limitations of direct digital radiography, ultrasound and computed tomography in diagnosing pleural mesotelioma. Collegium Antropologicum, 34 (4). pp. 1263-1271. ISSN 0350-6134

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    Croatian abstract

    MOGUĆNOSTI I OGRANIČENJA DIREKTNE DIGITALNE RADIOGRAFIJE, ULTRAZVUKA I KOMPJUTORIZIRANE TOMOGRAFIJE U DIJAGNOSTICI MEZOTELIOMA PLEURE ----- Cilj istraživanja je bio usporediti mogućnosti i ograničenja direktne digitalne radiografije prsišta (DDR), ultrazvuka prsišta (UZV) i kompjutorizirane tomografije prsišta (CT) u otkrivanju mezotelioma pleure. Istraživanje je provedeno tijekom godine dana, na 80 bolesnika, uzastopno upućenih u specijaliziranu ustanovu, s kliničkom sumnjom na mezoteliom. Metoda istraživanja bila je usporedba nalaza dobivenih ispitivanim metodama sa patohistološkim nalazom biopsije za svakog bolesnika. Nalazi dobiveni navedenim metodama klasificirani su prema pronađenim radiološkim znacima, za svakog pacijenta posebno. Svakom od korištenih metoda analizirani su sljedeći radiološki znakovi: pleuralni izljev, zadebljanja pleure, plakovi, kalcifikati, tumorske mase ili nodusi, pneumotoraks, atelektaza, upalni infiltrate, ožiljne lezije, elevacija ošita i osteoliza. Dobiveni rezultati uspoređeni su s patohistološkim nalazom i obrađeni standardnim statističkim metodama. Najveću osjetljivost pokazao je CT (94,4%). Slijedi UZV (92,6%), te DDR (90,7%). Najveća je specifičnost DDR (46,2%), slijedi CT (35, 5%) i UZV (23, 8%). Usporedba metoda pokazala je 90% dijagnostičku točnost DDR-e u odnosu na CT. UZV je pokazao točnost od 80% u odnosu na CT. CT, kao pojedinačna metoda, najbolje zadovoljava većinu kriterija za dijagnostiku mezotelioma. Nije nađen patognomoničan radiološki znak za dijagnozu mezotelioma.

    English abstract

    The goal of this study was to compare the possibilities and limitations of direct digital radiography of the chest (DDR), the use of ultrasound of the chest (US) and single slice computed tomography of the chest (CT) in diagnosing pleural mesothelioma. The study was conducted during the course of one year, on 80 patients who were successively referred to a specialized institution, under clinical suspicion of mesothelioma. The method of investigation was the comparison of findings, obtained by the reviewed methods of examination, with the pathohistologic results of a biopsy performed on each patient. The findings that were obtained by the enumerated methods were classified according to the radiologic signs that were found in each individual patient. We evaluated following radiological findings (signs), on each of the investigated methods: plaques, localized and generalized pleural thickenings, calcifications of the pleura, pleural effusions, parapneumonic effusions, pleural empyema, (round) atelectasis, pneumothorax, tumor mass or node, inflammatory infiltrate, elevation of the hemidiaphragm and osteolysis. The results of these were compared with pathohistologic findings and analyzed by means of standard statistical methods. The highest sensitivity was found for CT (94.4 %), followed by US (92.6%), and by DDR (90.7%). The highest specificity was obtained with DDR (46.2 %), followed by CT (35.5%) and US (23.8%). The comparison of these methods showed 90% diagnostic accuracy for DDR in relation to CT. CT as an individual method best satisfied most of the criteria for diagnosing mesothelioma. No pathognomonic radiologic sign for mesothelioma was found.

    Item Type: Article
    Divisions: Katedra za internu medicinu
    Katedra za radiologiju i opću kliničku onkologiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Popić Ramač, Jelena
    Hebrang, Andrija
    Ivanovi-Herceg, Zlata
    Vidjak, Vinko
    Brnić, Zoran
    Novačić, Karlo
    Fistonić, Ivan
    Date: December 2010
    Date Deposited: 16 Feb 2011
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/939

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