Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Serum immunoglobulins in non-Hodgkin's lymphoma patients

Planinc-Peraica, Ana and Ostojić Kolonić, Slobodanka and Radić-Krišto, Delfa and Dominis, Mara and Jakšić, Branimir (2010) Serum immunoglobulins in non-Hodgkin's lymphoma patients. Collegium Antropologicum, 34 (2). pp. 407-11. ISSN 0350-6134

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    Croatian abstract

    SERUMSKI IMUNOGLOBULINI U BOLESNIKA SE NE-HODGKINOVIM LIMFOMOM ----- Analizirali smo nalaze serumskih bjelančevina i imunoglobulina (Ig) u 119 bolesnika sa ne-Hodgkinovim limfomom (NHL). U 96 (81%) bolesnika dijagnosticiran je B-NHL, a u 23 (19%) T-NHL, mnogo češće indolentni tip (77 bolesnika, 65%), nego agresivni tip (42 bolesnika, 35%). U većine bolesnika koncentracija serumskih bjelančevina je bila u granicama normale. Povišena koncentracija serumskih bjelančevina je nađena u 17%, a snižena u 7% bolesnika. Hipoalbuminemija je mnogo češća (43%) nego hiperalbuminemija (1%). Za razliku od serumskog albumina, niske razine drugih proteinskih frakcija su vrlo rijetke (0.6% bolesnika ima snižene alfa1-, 4% bolesnika ima snižene alfa-2 i 3% bolesnika ima snižene beta-globuline), a povišene znatno češće (23% alfa-1, 37% alfa-2 i 8% beta-globulini). Poliklonalna hiperimunoglobulinemija je češća nego hipoimunoglobulinemija. U 29% bolesnika nađena je povišena razina IgG i u 25% bolesnika povišena razina IgA. Hipoimunoglobuinemija IgM (22%) je mnogo češća nego IgG (11%) i IgA (8%). U 11 (7%) bolesnika u elektroforezi serumskih bjelančevina nađena je monoklonalna gamapatija. Nije nađena statistički značajna povezanost između koncentracije serumskih imunoglobulina i stupnja malignosti limfoma kao niti između koncentracije serumskih imunoglobulina i imunološkog porijekla limfoma. Bolesnici sa T-NHL imaju češće koncentraciju IgA iznad ili ispod normalnih vrijednosti nego bolesnici s B-NHL (p<0,05).

    English abstract

    Serum proteins and immunoglobulin (Ig) findings in 119 non-Hodgkin's lymphoma (NHL) patients were analysed. Out of them 96 (81%) patients had B non-Hodgkin lymphoma (B-NHL), and 23 (19%) T-NHL. Indolent type of NHL was more frequent (77 patients, 65%), then aggressive type of NHL (42 patients, 35%). Most patients had normal serum protein concentration, the increased protein concentration was seen in 17% of patients while decreased concentration was noticed in 7% of patients. Hypoalbuminaemia was more frequent (43%) then hyperalbuminaemia (1%). In contrast to albumin, low levels of other protein fractions (alpha1-, alpha2-, and beta-globulin) were rather rare (0.6%, 4%, and 3% of patients, respectively) and high levels were frequent (23%, 37%, and 8%, respectively). Polyclonal hyperimmunoglobulinaemia was more frequent finding than hypoimmunoglobulinaemia. In 29% patients higher IgG level and in 25% patients higher IgA level were found. IgM hypoimmunoglobulinaemia (22%) was more frequent than IgG (11%) and IgA (8%) hypoimmunoglobulinaemia. M-spike in serum protein electrophoresis was found in 11 (7%) patients. The statistically significant association was not found between serum Ig concentration and lymphoma malignancy grade as well as between serum Ig concentration and immunologic origin of lymphoma. T-NHL patients have more often IgA concentration level above or under normal values than B-NHL patients (p < 0.05).

    Item Type: Article
    MeSH: Adult ; Blood Proteins/analysis ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Immunoglobulins/blood ; Lymphoma, Non-Hodgkin/blood ; Lymphoma, Non-Hodgkin/immunology ; Lymphoma, Non-Hodgkin/pathology ; Retrospective Studies ; Serum Albumin/metabolism ; Serum Globulins/metabolism
    Divisions: Katedra za internu medicinu
    Katedra za patologiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Planinc-Peraica, Ana
    Ostojić Kolonić, Slobodanka
    Radić-Krišto, Delfa
    Dominis, Mara
    Jakšić, Branimir
    Date: June 2010
    Date Deposited: 26 Nov 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/902

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