Rare infections mimicking MS

Brinar, Vesna V. and Habek, Mario (2010) Rare infections mimicking MS. Clinical Neurology and Neurosurgery, 112 (7). pp. 625-8. ISSN 0303-8467

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The diagnosis of multiple sclerosis (MS), despite well defined clinical criteria is not always simple. On many occasions it is difficult to differentiate MS from various non-MS idiopathic demyelinating disorders, specific and infectious inflammatory diseases or non-inflammatory demyelinating diseases. Clinicians should be aware of various clinical and MRI "red flags" that may point to the other diagnosis and demand further diagnostic evaluation. It is generally accepted that atypical clinical symptoms or atypical neuroimaging signs determine necessity for broad differential diagnostic work up. Of the infectious diseases that are most commonly mistaken for MS the clinician should take into account Whipple's disease, Lyme disease, Syphilis, HIV/AIDS, Brucellosis, HHV-6 infection, Hepatitis C, Mycoplasma and Creutzfeld-Jacob disease, among others. Cat scratch disease caused by Bartonella hensellae, Mediterranean spotted fever caused by Riketssia connore and Leptospirosis caused by different Leptospira serovars rarely cause focal neurological deficit and demyelinating MRI changes similar to MS. When atypical clinical and neuroimaging presentations are present, serology on rare infectious diseases that may mimic MS may be warranted. This review will focus on the infectious diseases mimicking MS with presentation of rare illustrative cases.

Item Type: Article
MeSH: Adult ; Bartonella henselae ; Boutonneuse Fever/complications ; Boutonneuse Fever/pathology ; Brain/pathology ; Cat-Scratch Disease/complications ; Cat-Scratch Disease/diagnosis ; Diagnosis, Differential ; Humans ; Infection/diagnosis ; Leptospira ; Leptospirosis/complications ; Leptospirosis/pathology ; Magnetic Resonance Imaging ; Male ; Multiple Sclerosis/diagnosis ; Rare Diseases ; Rickettsia conorii
Departments: Katedra za neurologiju
Depositing User: Marijan Šember
Status: Published
Date: September 2010
Date Deposited: 16 Nov 2010
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/877

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