Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Effect of osmolarity on CSF volume during ventriculo-aqueductal and ventriculo-cisternal perfusions in cats

Maraković, Jurica and Orešković, Darko and Radoš, Milan and Vukić, Miroslav and Jurjević, Ivana and Chudy, Darko and Klarica, Marijan (2010) Effect of osmolarity on CSF volume during ventriculo-aqueductal and ventriculo-cisternal perfusions in cats. Neuroscience Letters, 484 (2). pp. 93-7. ISSN 0304-3940

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    English abstract

    The effect of cerebrospinal fluid (CSF) osmolarity on the CSF volume has been studied on different CSF/brain tissue contact areas. It has been shown, on anesthetized cats under normal CSF pressure, that the perfusion of CSF system (12.96 μl/min) by hyperosmolar CSF (400 mOsml/l) leads to significantly higher outflow volume (μl/min) during ventriculo-cisternal perfusion (29.36 ± 1.17 and 33.50 ± 2.78) than the ventriculo-aqueductal perfusion (19.58 ± 1.57 and 22.10 ± 2.31) in experimental period of 30 or 60 min. Both of these hyperosmolar perfusions resulted in significantly higher outflow volume than the perfusions by isoosmolar artificial CSF (12.86 ± 0.96 and 13.58 ± 1.64). These results suggest that the volume of the CSF depends on both the CSF osmolarity and the size of the contact area between CSF system and surrounding tissue exposed to hyperosmolar CSF. However, all of these facts imply that the control of the CSF volume is not in accordance with the classical hypothesis of cerebrospinal fluid hydrodynamic. According to this hypothesis, the CSF volume should be regulated by active formation of CSF (secretion) inside the brain ventricles and passive CSF absorption outside of the brain. Obtained results correspond to the new hypothesis which claims that the volume of CSF depends on the gradients of hydrostatic and osmotic forces between the blood on one side and extracellular fluid and CSF on the other. The CSF exchange between the entire CSF system and the surrounding tissue should, therefore, be determined by (patho)physiological conditions that predominate within those compartments.

    Item Type: Article
    Divisions: Katedra za farmakologiju
    Hrvatski institut za istraživanje mozga
    Depositing User: Marijan Šember
    Status: Published
    Maraković, Jurica
    Orešković, Darko
    Radoš, Milan
    Vukić, Miroslav
    Jurjević, Ivana
    Chudy, Darko
    Klarica, Marijan
    Date: 29 October 2010
    Date Deposited: 16 Nov 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
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