Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma

Demirović, Alma and Džombeta, Tihana and Tomas, Davor and Spajić, Borislav and Pavić, Ivana and Hudolin, Tvrtko and Milošević, Milan and Čupić, Hrvoje and Krušlin, Božo (2010) Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma. Pathology - Research and Practice, [Epub . ISSN 0344-0338

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Abstract

The distinction between renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC), especially the eosinophilic variant, can often be difficult. Our study has documented for the first time the expression of MAGE-A3/4 and NY-ESO-1 cancer testis antigens (CTAs) in these tumors. A total of 35 patients (17 ROs and 18 ChRCCs) were included in the study. Two antibodies were used for immunohistochemical staining: 57B recognizing multiple MAGE-A and D8.38 recognizing NY-ESO-1 CTAs. Fifteen (88.2%) samples of RO stained positively for both MAGE-A3/4 and NY-ESO-1 antigens. Regarding ChRCC, seven (38.9%) stained positively for MAGE-A3/4 and six (33.3%) for NY-ESO-1 antigens. Median MAGE-A3/4 expression was moderately positive in RO and negative in ChRCC. The difference in MAGE-A3/4 expression between two tumor groups was significant (P=0.0013). Median NY-ESO-1 expression was strongly positive in RO and negative in ChRCC. The difference in NY-ESO-1 expression between two tumor groups was also significant (P=0.0008). Our study has shown that RO had a significantly higher expression of both CTAs. However, additional research is needed to clarify their potential diagnostic implications.

Item Type: Article
Departments: Katedra za patologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Demirović, AlmaUNSPECIFIED
Džombeta, TihanaUNSPECIFIED
Tomas, DavorUNSPECIFIED
Spajić, BorislavUNSPECIFIED
Pavić, IvanaUNSPECIFIED
Hudolin, TvrtkoUNSPECIFIED
Milošević, MilanUNSPECIFIED
Čupić, HrvojeUNSPECIFIED
Krušlin, BožoUNSPECIFIED
Date: 28 June 2010
Date Deposited: 09 Jul 2010
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/835

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