Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Cytogenetics of multiple myeloma

Lasan Trčić, Ružica and Kardum Skelin, Ika and Šušterčić, Dunja and Planinc-Peraica, Ana and Ajduković, Radmila and Hariš, Višnja and Kušec, Rajko and Begović, Davor (2010) Cytogenetics of multiple myeloma. Collegium Antropologicum, 34 (1). pp. 41-4. ISSN 0350-6134

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    Croatian abstract

    CITOGENETSKI REZULTATI 24 SLUČAJA MULTIPLOG MIELOMA ----- Velika ispitivanja multiplog mieloma (MM) naglašavaju da su određene kromosomske promjene od indikativnog značaja za pacijente s MM. Izvršili smo citogenetičke analize, a i u novije vrijeme i florescentnu in situ hibridizaciju (FISH) na 43 slučaja sa MM. Klonske kromosomske promjene bile su prisutne kod 24 (56%) slučaja. Hiperdiploidni kariotip je nađen kod 12 (50%) slučaja, hipodiploidni kod 8 (33%) slučaja, i 4 (17%) slučaja imalo je pseudodiploidni kariotip. Najčešće brojčane nepravilnosti bile su suvišci kromosoma 15, 11, 3 i 6. Manjak čitavih kromosoma bili su česti kod kromosoma X, 13, 14, i 8. Većina slučajeva također je pokazala strukturalne preuredbe 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t (11;14)(q13;q32) (n=4,17%). Kromosom – 13/13q delecija nađen je u 42% (n=10) slučaja, potpuni gubitak kromosoma 13 uočen je kod 67% (n=7) slučaja, dok je 33% (n=3) bilo s intersticijskom delecijom. U većini slučajeva bile su uz abnormalne prisutne i normalne metafaze.

    English abstract

    Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.

    Item Type: Article
    MeSH: Aged ; Aged, 80 and over ; Aneuploidy ; Biopsy, Needle ; Bone Marrow/pathology ; Chromosome Aberrations ; Chromosome Banding ; Chromosome Deletion ; Female ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Multiple Myeloma/pathology ; Prognosis ; Translocation, Genetic
    Divisions: Katedra za pedijatriju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Lasan Trčić, Ružica
    Kardum Skelin, Ika
    Šušterčić, Dunja
    Planinc-Peraica, Ana
    Ajduković, Radmila
    Hariš, Višnja
    Kušec, Rajko
    Begović, Davor
    Date: March 2010
    Date Deposited: 04 Jun 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/806

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