Cytogenetics of multiple myeloma

Lasan Trčić, Ružica and Kardum Skelin, Ika and Šušterčić, Dunja and Planinc-Peraica, Ana and Ajduković, Radmila and Hariš, Višnja and Kušec, Rajko and Begović, Davor (2010) Cytogenetics of multiple myeloma. Collegium Antropologicum, 34 (1). pp. 41-4. ISSN 0350-6134

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Abstract

Great studies of multiple myeloma (MM) strongly suggested that specific chromosomal changes are of prognostic significance in patients with MM1. We have performed cytogenetic analysis and recently fluorescent in situ hybridization (FISH) on 43 cases of MM. Clonal chromosomal changes were present in 24 (56%) cases. Hyperdiploid karyotype was found in 12 (50%) cases, hypodiploid in 8 (33%) cases, and 4 (17%) cases had a pseudodiploid karyotype. The most common numerical abnormalities were gains of whole chromosomes 15, 11, 3 and 6. Whole chromosome losses were also frequent involving chromosomes X, 13, 14, and 8. Most cases showed also structural rearrangements 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t(11;14)(q13;q32) (n=4, 17%). Chromosome –13/13q deletion was found in 42% (n=10) cases; complete loss of 13 was observed in 67% (n=7) cases, whereas 33% (n=3) had interstitial deletions. In the majority of the cases there was a mixture of abnormal and normal metaphases.

Abstract in Croatian

CITOGENETSKI REZULTATI 24 SLUČAJA MULTIPLOG MIELOMA ----- Velika ispitivanja multiplog mieloma (MM) naglašavaju da su određene kromosomske promjene od indikativnog značaja za pacijente s MM. Izvršili smo citogenetičke analize, a i u novije vrijeme i florescentnu in situ hibridizaciju (FISH) na 43 slučaja sa MM. Klonske kromosomske promjene bile su prisutne kod 24 (56%) slučaja. Hiperdiploidni kariotip je nađen kod 12 (50%) slučaja, hipodiploidni kod 8 (33%) slučaja, i 4 (17%) slučaja imalo je pseudodiploidni kariotip. Najčešće brojčane nepravilnosti bile su suvišci kromosoma 15, 11, 3 i 6. Manjak čitavih kromosoma bili su česti kod kromosoma X, 13, 14, i 8. Većina slučajeva također je pokazala strukturalne preuredbe 71% (n=17): del(1p), dup(1q), del(5q), del(13q), del(17p) and t (11;14)(q13;q32) (n=4,17%). Kromosom – 13/13q delecija nađen je u 42% (n=10) slučaja, potpuni gubitak kromosoma 13 uočen je kod 67% (n=7) slučaja, dok je 33% (n=3) bilo s intersticijskom delecijom. U većini slučajeva bile su uz abnormalne prisutne i normalne metafaze.

Item Type: Article
MeSH: Aged ; Aged, 80 and over ; Aneuploidy ; Biopsy, Needle ; Bone Marrow/pathology ; Chromosome Aberrations ; Chromosome Banding ; Chromosome Deletion ; Female ; Gene Rearrangement ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Multiple Myeloma/pathology ; Prognosis ; Translocation, Genetic
Departments: Katedra za pedijatriju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Lasan Trčić, RužicaUNSPECIFIED
Kardum Skelin, IkaUNSPECIFIED
Šušterčić, DunjaUNSPECIFIED
Planinc-Peraica, AnaUNSPECIFIED
Ajduković, RadmilaUNSPECIFIED
Hariš, VišnjaUNSPECIFIED
Kušec, RajkoUNSPECIFIED
Begović, DavorUNSPECIFIED
Date: March 2010
Date Deposited: 04 Jun 2010
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/806

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