Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report

Barišić, Ana and Mahovlić, Vesna and Ovanin-Rakić, Ana and Škopljanac-Mačina, Lada and Rajhvajn, Sanda and Jurič, Danijela and Babić, Damir (2010) Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri--case report. Collegium Antropologicum, 34 (1). pp. 233-5. ISSN 0350-6134

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Croatian abstract

CITOLOŠKE KARAKTERISTIKE ADENOID CISTIČNOG KARCINOMA VRATA MATERNICE – PRIKAZ SLUČAJA ----- Adenoid cistični karcinom je rijetka maligna neoplazma koju obično nalazimo u žlijezdama slinovnicama, iako se ovaj tumor pojavljuje i u drugim dijelovima tijela. U slučaju bolesti vrata maternice, adenoid cistični karcinom je izrazito rijedak, obično u postmenopauzi. U literaturi je opisano svega nekoliko slučajeva u citološkim uzorcima vrata maternice. U našem radu prikazan je slučaj 74-godišnje pacijentice s krvarenjem u postmenopauzi. Analizirani su Papa razmaz kao i obrisak vrata maternice osušen na zraku te obojen po Papenheimu. Citološki, nađene su malobrojne nakupine malignih žlijezdanih stanica, kao i nešto amorfnih eozinofilnih globula. Na nekrotičnoj pozadini prevladavala je slika granulomatozne upale s brojnim histiocitima, multinuklearnim orijaškim stanicama, velikim nakupinama epiteloidnih stanica i s dosta limfocita. Histološka dijagnoza je bila adenoid cistični karcinom. U slučajevima sumnjivog kliničkog nalaza na vratu maternice kod žena u postmenopauzi vrlo je važno pažljivo pregledati Papa razmaz te svakako treba misliti i na adenoid cistični karcinom vrata maternice.

English abstract

Adenoid cystic carcinoma is a rare malignancy, usually found in the salivary glands, although this unusual tumor can be found at other sites of the body. In particular, regarding adenoid cystic carcinoma of the cervix (ACCC) most frequently reports are given for postmenopausal women. In this respect, our work is one among very few in the literature that considers a cytologic picture of this uncommon cervix carcinoma. The case of 74 year old patient with postmenopausal bleeding is described. Both Pap smear and air dried smear of the uterine cervix were analyzed. The cytologic findings revealed very few small clusters of abnormal glandular cells, as well as some amorphous eosinophilic globule-like material, with granulomatous and necrotic background. The latter includes a lot of histiocytes, multinucleated giant cells, large aggregates of epitheloid cells and lymphocytes. Histology revealed the diagnosis of ACCC. We emphasize the importance of careful screening of Pap smear that might be crucial in the case of suspicious clinical findings in postmenopausal women, when the possibility of ACCC has to be considered.

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