Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

FNA based diagnosis of head and neck nodal lymphoma

Gjadrov Kuveždić, Koraljka and Aurer, Igor and Ries, Sunčica and Sučić, Mirna and Marković Glamočak, Mirjana and Ilić, Ivana and Bašić-Kinda, Sandra and Radman, Ivo and Labar, Boris (2010) FNA based diagnosis of head and neck nodal lymphoma. Collegium Antropologicum, 34 (1). pp. 7-12. ISSN 0350-6134

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    Croatian abstract

    CITOMORFOLOŠKA DIJAGNOZA LIMFOMA U PODRUČJU GLAVE I VRATA ----- Citomorfološka analiza uzorka dobivenog punkcijom tankom iglom neizostavna je metoda u dijagnostici i praćenju liječenja promjena u području glave i vrata. U dijagnostici limfoma citomorfološka analiza uzorka služi kao metoda probira za odabir zahvaćenog čvora za otvorenu ili biopsiju širokom iglom. Prema Klasifikaciji limfoidnih novotvorina Svjetske zdravstvene organizacije danas je potrebno prepoznati staničnu morfologiju, te uz nalaze imunofenotipizacije i genetičkih analiza, kao i kliničkih pokazatelja odlučiti o terapiji odgovarajućoj za pojedinog bolesnika. Cilj ove studije bio je utvrditi učinkovitost citomorfološke i imunocitokemijske analize u dijagnostici limfoma u području glave i vrata. U retrospektivnom istraživanju pregledali smo sve slučajeve tijekom trogodišnjeg perioda, sa citomorfološkom dijagnozom ili kliničkom sumnjom na novootkriveni limfom ili relapsom već postojeće bolesti. U studiju su bili uključeni pacijenti upućeni u našu ambulantu od hematologa, sa povećanim limfnim čvorom u području glave i vrata, kojima je citomorfološka analiza prethodila ostalim dijagnostičkim postupcima. Učinjeno je 285 aspiracijskih punkcija u 248 pacijenata koji su ispunili uvjete za studiju. Uzorci adekvatni za citomorfološku analizu dijagnosticirani su kao limfom u 100 slučajeva (36%), kod 65 pacijenata i 35 pacijentica, 76 kod pacijenata sa novo-otkrivenom bolešću, 24 kod bolesnika s prijašnjom dijagnozom limfoma. Osjetljivost citomorfološke analize u dijagnostici limfoma u području glave i vrata iznosila je 90%, specifičnost 88%, prediktivna vrijednost pozitivnog testa 97%, prediktivna vrijednost negativnog testa 61%. Prema našim rezultatima citomorfološka analiza, upotpunjena imunocitokemijskim određivanjem limfatičnih biljega može postati metoda izbora u primarnoj dijagnostici limfoma, kao metoda komplementarna patohistološkoj analizi.

    English abstract

    Fine-needle aspiration (FNA) biopsy has become a well established technique in the diagnosis, staging, and follow-up of patients with head and neck lesions. As in lymphoma diagnostics, FNA serves as a screening method in evaluating potentially affected lymph node for open or core biopsy. According to the World Health Organization classification of lymphoid neoplasms, today it is important to recognize cell morphology and reveal its phenotype, then combine it with different genotypic information and clinical data to provide appropriate therapy. The aim of this study was to assess the efficacy of FNA and immunocytochemistry based lymphoma diagnostic in head and neck region. We conducted a retrospective study during a period of three years where cases with either FNA diagnosis or clinical suspicion of newly recognized or relapsing lymphoma were reviewed. In the study were included patients that were referred to our laboratory from hematology department, in whom head and neck lymphadenopathia was found and lymph node FNA preceded other procedures. Two hundred eighty-five aspirations from 248 patients fulfilled study criteria. Adequate specimens were diagnosed as lymphoma in 100 cases (36%), in 65 male and 35 female patients, 76 in patients with newly discovered disease and 24 in patients with prior lymphoma diagnosis. Overall sensitivity of FNA specimens in the diagnosis of head and neck lymphomas was 90%, specificity 88%, predictive value of a positive result 97%, and predictive value of negative result 61%. Based on our results FNA corroborated with immunophenotyping by immunocytochemistry can be method of choice in primary lymphoma diagnosis as a method complementary to histopathology in lymphoma diagnostics.

    Item Type: Article
    MeSH: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle/standards ; Child ; Child, Preschool ; Dermatitis, Contact ; Female ; Follow-Up Studies ; Head and Neck Neoplasms/pathology ; Humans ; Immunohistochemistry ; Infant ; Lymphatic Metastasis/pathology ; Lymphoma/pathology ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging/methods ; Neoplasm Staging/standards ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; World Health Organization ; Young Adult
    Divisions: Katedra za internu medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Gjadrov Kuveždić, Koraljka
    Aurer, Igor
    Ries, Sunčica
    Sučić, Mirna
    Marković Glamočak, Mirjana
    Ilić, Ivana
    Bašić-Kinda, Sandra
    Radman, Ivo
    Labar, Boris
    Date: March 2010
    Date Deposited: 26 May 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/797

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