The occurrence of hemorrhagic fever with renal syndrome in southern parts of Bosnia and Herzegovina [Pojavnost hemoragijske vrućice s bubrežnim sindromom u južnim područjima Bosne i Hercegovine]

Nikolić, Jadranka and Kuzman, Ilija and Markotić, Alemka and Đaković Rode, Oktavija and Curić, Ivo and Bebek Ivanković, Helien and Grgić, Svjetlana (2009) The occurrence of hemorrhagic fever with renal syndrome in southern parts of Bosnia and Herzegovina [Pojavnost hemoragijske vrućice s bubrežnim sindromom u južnim područjima Bosne i Hercegovine]. Collegium Antropologicum, 33 (S. 2). pp. 37-42. ISSN 0350-6134

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Abstract

Bosnia and Herzegovina (B&H) has been known as an endemic region for hemorrhagic fever with renal syndrome (HFRS) for over 50 years. Multiple epidemics of this disease have been registered so far, especially in endemic parts of Central and Northeastern Bosnia, as well as the Sarajevo region. Seroepidemiological investigations demonstrate naturalization of Hantaviruses and their wide spread in B&H. However, there are no studies from the southern areas of B&H, and endemic foci of this disease are unknown. The aim of this study was to determine the distribution and serologic prevalence of Hantavirus infections by testing for specific IgG antibodies against hantaviruses in the population of Herzegovina. This study included two groups of participants. The target group consisted of 300 participants from exposed professional and population groups, and control group included 100 educators with lower exposure to HFRS. Identification of specific IgG antibodies against hantaviruses in 16 participants confirmed an initial assumption about the presence of Hantavirus infections in the region of interest. Seroprevalence of 5% was registered in the »exposed« and 1% in the »unexposed« group. Simultaneous circulation of Puumala (PUU) and Dobrava (DOB) viruses was discovered. The frequency of positive antibody results was higher in the population above 50 years of age, and three times more prevalent in men then at women. The highest proportion of exposed participants (80%) was registered in the municipalities which geographically belong to high or mountainous Herzegovina.

Abstract in Croatian

Bosna i Hercegovina (BiH) je više od 50 godina poznata kao endemska regija hemoragijske vrućice s bubrežnim sindromom (HVBS). Do sada je registrirano više epidemija ove bolesti, poglavito u endemskim dijelovima središnje i sjeveroistočne Bosne, te u sarajevskoj regiji. Seroepidemiološka istraživanja potvrđuju udomaćenost hantavirusa i njihovu distribuciju u BiH. Međutim, do sada nisu provedena nikakva seroepidemiološka istraživanja u južnim područjima BiH, niti su poznata prirodna žarišta ove bolesti. Cilj ovog istraživanja bio je seroepidemiološkim istraživanjem i nalazom specifičnih IgG protutijela na hantaviruse utvrditi rasprostranjenost i seroprevalenciju hantavirusnih infekcija u Hercegovini. U istraživanje su uključene dvije skupine ispitanika. Ciljana skupina obuhvaća 300 ispitanika iz izloženih profesionalnih i populacijskih skupina, a kontrolna skupina 100 prosvjetnih djelatnika, koji imaju manju izloženost HVBS-u. Nalazom specifičnih IgG protutijela na hantaviruse kod 16 ispitanika potvrđena je polazišna pretpostavka o pojavnosti hantavirusnih infekcija i u istraživanom području. Kod ispitanika u izloženoj skupini bilježi se seroprevalencija od 5%, a u neizloženoj skupini 1%. Otkrivena je istodobna cirkulacija Puumala i Dobrava virusa. Češća prokuženost registrira se u starijih od 50 godina, a triput je veća kod muškaraca nego u žena. Najviše prokuženih ispitanika (80%) registrira se u općinama koje zemljopisno pripadaju visokoj ili planinskoj Hercegovini.

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