Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Primary glomangioma of the esophagus mimicking esophageal papilloma

Tomas, Davor and Tomić, Karla and Bekavac-Bešlin, Miroslav and Jukić, Zoran and Belicza, Mladen and Krušlin, Božo (2006) Primary glomangioma of the esophagus mimicking esophageal papilloma. Diseases of the Esophagus, 19 (3). pp. 208-11. ISSN 1120-8694

[img]
Preview
PDF
Download (1033Kb) | Preview

    English abstract

    We report a case of glomangioma of the esophagus in a 28-year-old woman who presented with a 3-year history of vague discomfort, pain and heat in the neck. At initial gross examination, the tumor mimicked an esophageal papilloma. The resected esophageal specimen contained a polypoid, whitish-gray mass, which measured 3 cm in maximum diameter. Microscopically the tumor consisted of loose fibrovascular stroma heavily infiltrated with mononuclear inflammatory cells and covered with focally hyperkeratotic, parakeratotic and acanthotic squamous epithelium without atypia. In the deeper area immediately above the true muscular layer of the esophageal wall, microscopical examination revealed the neoplasm consisting of numerous, small-to-medium branched vessels covered by regular endothelium and filled with erythrocytes. The loose stroma around the vessels contained poorly circumscribed nests of small, round to oval cells with a uniform appearance. Immunohistochemically, the tumor cells were immunoreactive for smooth muscle actin and vimentin and non-immunoreactive for CD34, CD117, desmin, pan-cytokeratin, synaptophisin, neuron-specific enolase and S-100 protein. Despite its bland histology, the infiltrative growth pattern was suggestive of aggressive behavior; thus, an appropriate clinical follow-up was recommended. An accurate diagnosis and an understanding of the behavior of these rare tumors, especially in an unusual location, are crucial to their management and clinical outcome.

    Item Type: Article
    MeSH: Adult ; Diagnosis, Differential ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/metabolism ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Female ; Glomus Tumor/diagnosis ; Glomus Tumor/metabolism ; Glomus Tumor/pathology ; Glomus Tumor/surgery ; Humans ; Immunohistochemistry ; Papilloma/diagnosis
    Divisions: Katedra za patologiju
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Tomas, Davor
    Tomić, Karla
    Bekavac-Bešlin, Miroslav
    Jukić, Zoran
    Belicza, Mladen
    Krušlin, Božo
    Date: June 2006
    Date Deposited: 01 Mar 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/725

      Actions (login required)

      View Item

      Document Downloads

      More statistics for this item...