Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Quetiapine augmentation in treatment-resistant depression: a naturalistic study

Šagud, Marina and Mihaljević-Peleš, Alma and Muck-Šeler, Dorotea and Jakovljević, Miro and Pivac, Nela (2006) Quetiapine augmentation in treatment-resistant depression: a naturalistic study. Psychopharmacology, 187 (4). pp. 511-514. ISSN 0033-3158 (Print) 1432-2072 (Electronic)

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    English abstract

    Rationale Treatment-resistant depression (TRD) is a common clinical problem, often complicated with suicidal ideations and greater lifetime functional impairment, and represents a considerable challenge to management and treatment. - - - - - Objective The aim of a prospective, open-label, noncomparative, flexible-dosed 20-week study was to evaluate the effects of quetiapine, as an add-on therapy, in patients with TRD who were refractory to previous treatments. - - - - - Method Eighteen patients with major depressive disorder (DSM-IV criteria) were treated for 20 weeks with quetiapine (mean dose 315 +/- 109 mg/day). Patients were evaluated at baseline, weekly from 1 to 9 weeks, and then after 12, 16, and 20 weeks of treatment, using Hamilton rating scale for depression-17 items (HAMD) scale. - - - - - Results Fourteen patients with TRD completed the 20-week open trial with quetiapine. The augmentation with quetiapine significantly reduced total scores and scores listed in the anxiety subscale on the HAMD, and these effects were observed after the fourth week of treatment, while the depressed mood scores were significantly reduced after the fifth week of treatment. Quetiapine add-on treatment significantly decreased the scores listed in the insomnia subscale on the HAMD subscale after the second week of treatment. - - - - - Conclusions Our preliminary data indicate that quetiapine add-on therapy appears to have beneficial effects in the treatment of patients with TRD.

    Item Type: Article
    MeSH: Antidepressive Agents - therapeutic use ; Antipsychotic Agents - therapeutic use ; Depressive Disorder, Major - drug therapy - psychology ; Dibenzothiazepines - therapeutic use ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Psychiatric Status Rating Scales ; Time Factors ; Treatment Outcome
    Divisions: Katedra za psihijatriju i psihološku medicinu
    Depositing User: Slaven Semper
    Status: Published
    Šagud, Marina
    Mihaljević-Peleš, Alma
    Muck-Šeler, Dorotea
    Jakovljević, Miro
    Pivac, Nela
    Date: September 2006
    Date Deposited: 01 Dec 2006
    Last Modified: 23 Sep 2011 18:09
    Subjects: /
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