Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Kidney volume and albuminuria as markers of birth weight - blood pressure relationship in essential hypertension

Laganović, Mario and Kuzmanić, Duško and Željković-Vrkić, Tajana and Pećin, Ivan and Dika, Živka and Jelaković, Bojan (2009) Kidney volume and albuminuria as markers of birth weight - blood pressure relationship in essential hypertension. Kidney & Blood Pressure Research, 32 (6). pp. 399-404. ISSN 1420-4096

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    English abstract

    Our aim was to analyze whether birth weight contributes to future hypertension through reduced kidney volume, and whether albuminuria could be a marker of this pathway. We included 103 patients with newly diagnosed essential hypertension and 92 normotensive controls. Blood pressure (BP) was measured using a mercury sphygmomanometer and a ABP monitor. Kidney volume was determined by ultrasound. Data on birth weight were obtained from mothers. Albuminuria was determined in 24-hour urine samples. Hypertensive patients had lower birth weight and higher albuminuria than normotensives. There was no difference in kidney volume between the two groups. We found a negative correlation between birth weight and systolic BP in the hypertensive group. BP was significantly correlated with BMI and albuminuria in the hypertensive group. Multiple regression analysis had shown the greatest impact of BMI on BP and had also demonstrated that 24-hour systolic BP showed the greatest risk for developing albuminuria in hypertensive patients. In conclusion, birth weight influences BP values in adult age, but it is not mediated by a reduced kidney volume. A strong correlation, independent of birth weight, was observed between albuminuria and BP values. Increased BMI is the most important independent risk factor responsible for BP increase, even in an early phase of essential hypertension.

    Item Type: Article
    Divisions: Katedra za internu medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Laganović, Mario
    Kuzmanić, Duško
    Željković-Vrkić, Tajana
    Pećin, Ivan
    Dika, Živka
    Jelaković, Bojan
    Date: November 2009
    Date Deposited: 03 Feb 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/707

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