Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Vascular endothelial growth factor in children with neuroblastoma: a retrospective analysis

Jakovljević, Gordana and Čulić, Srđana and Stepan, Jasminka and Bonevski, Aleksandra and Seiwerth, Sven (2009) Vascular endothelial growth factor in children with neuroblastoma: a retrospective analysis. Journal of Experimental & Clinical Cancer Research, 28 (143). ISSN 0392-9078

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    English abstract

    BACKGROUND: Despite aggressive therapy, advanced stage neuroblastoma patients have poor survival rates. Although angiogenesis correlates with advanced tumour stage and plays an important role in determining the tumour response to treatment in general, clinical data are still insufficient, and more clinical evaluations are needed to draw conclusions. The aim of this study was to evaluate vascular endothelial growth factor (VEGF) expression in patients with neuroblastoma, determine whether it correlates with other prognostic factors and/or therapeutic response, and to assess should VEGF be considered in a routine diagnostic workup. ----- MATERIALS AND METHODS: VEGF expression was determined by immunohistochemistry using anti-VEGF antibody in paraffin embedded primary tumour tissue from 56 neuroblastoma patients. Semiquantitative expression of VEGF was estimated and compared with gender, age, histology, disease stage, therapy, and survival. Statistical analyses, including multivariate analysis, were performed. ----- RESULTS: VEGF expression correlated with disease stage and survival in neuroblastoma patients. Combination of VEGF expression and disease stage as a single prognostic value for survival (P-value = 0.0034; odds ratio (OR) (95%CI) = 26.17 (2.97-230.27) exhibited greater correlation with survival than individually. Hematopoietic stem cell transplantation significantly improved survival of the advanced stage patients with high VEGF expression. ----- CONCLUSION: VEGF expression should be considered in a routine diagnostic workup of children with neuroblastoma, especially in those more than 18 months old and with advanced disease stage. High VEGF expression at the time of disease diagnosis is a bad risk prognostic factor, and can be used to characterize subsets of patients with an unfavourable outcome.

    Item Type: Article
    Divisions: Katedra za patologiju
    Depositing User: Marijan Šember
    Status: Published
    Jakovljević, Gordana
    Čulić, Srđana
    Stepan, Jasminka
    Bonevski, Aleksandra
    Seiwerth, Sven
    Date: 06 November 2009
    Date Deposited: 01 Feb 2010
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
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