Mechanical ventilation in chronic obstructive pulmonary disease patients, noninvasive vs. invasive method (randomized prospective study).

Jurjević, Matija and Matić, Ivo and Šakić-Zdravčević, Katarina and Šakić, Šimun and Đanić, Davorin and Buković, Damir (2009) Mechanical ventilation in chronic obstructive pulmonary disease patients, noninvasive vs. invasive method (randomized prospective study). Collegium antropologicum, 33 (3). pp. 791-797. ISSN 0350-6134

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Abstract

Acute respiratory failure due to chronic obstructive pulmonary disease (COPD) presents an increasing problem throughout the world. The aim of this study was to compare invasive and non-invasive mechanical ventilation (MV) for patients with COPD. A prospective, randomized trial was performed in a multidisciplinary intensive care unit for the period of 36 months and included 156 patients with COPD. MV procedure was performed using standard methods, and was applied as either invasive MV (IMV) or noninvasive MV (NIMV). Patients were randomized in two groups for application of MV using closed, nontransparent envelops. Comparison was made based on patient characteristics, objective parameters on admission and 1h, 4h, 24h, and 48h after admission and based on treatment outcome. We have confirmed that NIMV method is superior to IMV for patients with COPD. MV duration NIMV:IMV was 94:172 hours, p<0.001, time spent in Intensive Care Unit 120:223 hours, p<0.001. Ventilator associated pneumonia 5(6%):29(37%), p<0.001.The advantage of NIMV in COPD patients, especially in the early stages was confirmed.

Abstract in Croatian

USPOREDBA NEINVAZIVNE I INVAZIVNE UMJETNE VENTILACIJE KOD BOLESNIKA S KRONIČNOM OPSTRUKTIVNOM PLUĆNOM BOLESTI; PROSPEKTIVNA RANDOMIZIRANA STUDIJA ----- Akutno respiratorno zatajenje uzrokovano kroničnom opstruktivnom plućnom bolesti (KOPB) predstavlja rastući problem širom svijeta. Cilj ove studije bila je usporedba invazivne i neinvazivne umjetne ventilacije (UV) kod bolesnika sa KOPB. Ova prospektivna, randomizirana studija je trajala 36 mjeseci i provedena je u multidisciplinarnoj jedinici intenzivnog liječenja. Uključivala je 156 bolesnika sa KOPB. UV je provođena primjenom standardnih metoda, a primjenjivana je kao invazivna UV (IUV) ili neinvazivna UV (NIUV). Bolesnici su randomizirani u dvije skupine za primjenu UV korištenjem zatvorenih, neprozirnih omotnica. Usporedba je provedena na osnovi karakteristika bolesnika, objektivnih parametara kod prijema, 1h, 4h, 24h i 48h nakon prijema te na osnovi parametara ishoda liječenja. Istraživanje je potvrdilo prednost NIUV u odnosu na IUV kod bolesnika sa KOPB. Trajanje UV NIUV:IUV bilo je 94:172h, p<0,001, vrijeme provedeno u jedinici intenzivnog liječenja 120:223h, p<0,001. Pojavnost ventilator udružene pneumonije bila je 5(6%):29(37%), p<0,001. Potvrđena je prednost NIUV kod KOPB bolesnika, osobito u ranijim stadijima bolesti.

Item Type: Article
Departments: Katedra za anesteziologiju i reanimatologiju
Katedra za ginekologiju i opstetriciju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Jurjević, MatijaUNSPECIFIED
Matić, IvoUNSPECIFIED
Šakić-Zdravčević, KatarinaUNSPECIFIED
Šakić, ŠimunUNSPECIFIED
Đanić, DavorinUNSPECIFIED
Buković, DamirUNSPECIFIED
Date: September 2009
Date Deposited: 13 Nov 2009
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/688

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