Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Does the viral subtype influence the biennial cycle of respiratory syncytial virus?

Mlinarić-Galinović, Gordana and Vojnović, Gordana and Čepin-Bogović, Jasna and Baće, Ana and Božikov, Jadranka and Welliver, Robert C. and Wahn, Ulrich and Cebalo, Ljiljana (2009) Does the viral subtype influence the biennial cycle of respiratory syncytial virus? Virology journal, 6 (133). ISSN 1743-422X

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    English abstract

    BACKGROUND ----- The epidemic pattern of respiratory syncytial virus (RSV) is quite different in regions of Europe (biennial epidemics in alternating cycles of approximately 9 and 15 months) than in the Western Hemisphere (annual epidemics). In order to determine if these differences are accounted for by the circulation of different RSV subtypes, we studied the prevalence of RSV subtype A and B strains in Zagreb County from 1 January 2006 to 31 December 2007. RESULTS ----- RSV was identified in the nasopharyngeal secretions of 368 inpatients using direct fluorescence assays and/or by virus isolation in cell culture. The subtype of recovered strains was determined by real-time PCR. Of 368 RSV infections identified in children during this interval, subtype A virus caused 94 infections, and subtype B 270. Four patients had a dual RSV infection (subtypes A and B). The period of study was characterized by two epidemic waves of RSV infections-one, smaller, in the spring of 2006 (peaking in March), the second, larger, in December 2006/January 2007 (peaking in January). The predominant subtype in both outbreaks was RSV subtype B. Not until November 2007 did RSV subtype A predominate, while initiating a new outbreak continuing into the following calendar year. CONCLUSION ----- Though only two calendar years were monitored, we believe that the biennial RSV cycle in Croatia occurs independently of the dominant viral subtype.

    Item Type: Article
    Divisions: Katedra za bakteriologiju, virologiju i parasitologiju
    Katedra za medicinsku statistiku, epidemiologiju i medicinsku informatiku
    Depositing User: Marijan Šember
    Status: Published
    Mlinarić-Galinović, Gordana
    Vojnović, Gordana
    Čepin-Bogović, Jasna
    Baće, Ana
    Božikov, Jadranka
    Welliver, Robert C.
    Wahn, Ulrich
    Cebalo, Ljiljana
    Date: 07 September 2009
    Date Deposited: 12 Oct 2009
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
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