Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Količina i raspodjela abdominalne masti u osoba s morfološkim promjenama aorte kod MSCT aortografije

Hrabak Paar, Maja (2009) Količina i raspodjela abdominalne masti u osoba s morfološkim promjenama aorte kod MSCT aortografije. PhD thesis, Sveučilište u Zagrebu.

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    Croatian abstract

    Visceralna pretilost povezana je s razvojem metaboličkog sindroma i kardiovaskularnih bolesti. U našoj studiji istražili smo povezanost nastanka aneurizme abdominalne aorte i aterosklerotskih promjena aorte s količinom i raspodjelom abdominalnog masnog tkiva. Površina ukupnog, visceralnog i supkutanog abdominalnog masnog tkiva izmjerena je na CT presjeku u razini umbilikusa u 94 ispitanika s aneurizmom abdominalne aorte i 94 ispitanika kontrolne skupine te su izmjerene vrijednosti međusobno uspoređene. Pokazali smo da nastanak aneurizme abdominalne aorte nije povezan s količinom ukupnog i visceralnog masnog tkiva, dok supkutano masno tkivo ima „protektivni“ učinak na nastanak aneurizme. U kontrolnoj skupini određen je stupanj aterosklerotskih lezija segmenata aorte, te je utvrđeno da je količina visceralnog masnog tkiva pozitivno povezana s aterosklerotskim promjenama svih segmenata aorte, dok je učinak supkutanog masnog tkiva na razvoj aterosklerotskih promjena aorte zanemariv. Dobiveni rezultati upućuju na različitu etiopatogenezu aneurizmatskog proširenja aorte i stenozirajućih aterosklerotskih lezija.

    English abstract

    Visceral adiposity is related to development of metabolic syndrome and cardiovascular diseases. We evaluated the relationship between the amount and distribution of abdominal adipose tissue with development of abdominal aortic aneurysm and atherosclerotic changes of the aorta. Total, visceral and subcutaneous abdominal fat areas were measured on a single axial CT scan at the level of umbilicus in 94 patients with abdominal aortic aneurysm and in 94 control subjects. We found no relationship between abdominal aortic aneurysm development and total and visceral fat areas, while subcutaneous adipose tissue had „protective“ effect on aneurysm development. In the control group, atherosclerotic plaques of aortic segments were graded, and positive relationship between visceral fat area and atherosclerotic lesions of all aortic segments was seen. The effect of subcutaneous fat tissue on development of aortic atherosclerosis was negligible. Our results indicate that aneurysmatic dilatation of the aorta and stenosing atherosclerotic lesions could be caused by different pathophysiological mechanisms.

    Item Type: Thesis (PhD)
    Mentor: Štern-Padovan, Ranka
    Divisions: Izvan medicinskog fakulteta
    Depositing User: Marijan Šember
    University: Sveučilište u Zagrebu
    Institution: Medicinski fakultet
    Number of Pages: 86
    Status: Unpublished
    Creators:
    CreatorsEmail
    Hrabak Paar, Maja
    Date: 14 July 2009
    Date Deposited: 09 Sep 2009
    Last Modified: 23 Sep 2011 18:11
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/665

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