Dyslipidemia and adherence to the Mediterranean diet in Croatian HIV-infected patients during the first year of highly active antiretroviral therapy

Turčinov, Drago and Stanley, Christine and Canchola, Jesse A. and Rutherford, George W. and Novotny, Thomas E. and Begovac, Josip (2009) Dyslipidemia and adherence to the Mediterranean diet in Croatian HIV-infected patients during the first year of highly active antiretroviral therapy. Collegium antropologicum, 33 (2). pp. 423-430. ISSN 0350-6134

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Abstract

We investigated the association of adherence to the Mediterranean diet and other risk factors for dyslipidemia in HIV-infected Croatian patients during the first year of highly active antiretroviral therapy (HAART). Adherence to the Mediterranean diet was determined by a 150-item questionnaire; a 0 to 9-point diet scale was created that stratified respondents as having low adherence (<4 points) and moderate to high adherence (> or = 4 points). We interviewed 117 participants between May 2004 and June 2005 and abstracted their serum lipid measurements taken during the first year of HAART The values of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides increased most prominently in the first 3 to 6 months after initiation of HAART (average increase at 3 months: 25% for total cholesterol, 22% for LDL-cholesterol, 18% for HDL-cholesterol and 43% for triglycerides). A Mediterranean diet and physical activity had no effect on serum lipids. The mean total cholesterol was higher in participants receiving a combination of a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor compared to participants receiving a combination of nucleoside analogs with a non-nucleoside analog or a combination of nucleoside analogs and a protease inhibitor Among individual drug treatments, indinavir/ritonavir had the most unfavorable lipid profile. We conclude that adherence to a Mediterranean diet does not influence serum lipid profiles during the first year of HAART.

Abstract in Croatian

DISLIPIDEMIJA I PRIDRŽAVANJE MEDITERANSKOJ PREHRANI U BOLESNIKA IZ HRVATSKE ZA VRIJEME PRVE GODINE LIJEČENJA VRLO DJELOTVORNOM ANTIRETROVIRUSNOM TERAPIJOM ----- Istražili smo pridržavanje mediteranskoj prehrani i druge rizične čimbenike koji su povezani s dislipidemijom u bolesnika zaraženih HIV-om iz Hrvatske za vrijeme prve godine liječenja vrlo djelotvornom antiretrovirusnom terapijom (HAART). Pridržavanje mediteranskoj prehrani određeno je upitnikom od 150 pitanja; učinjena je skala od 0 do 9 stupnjeva po kojoj su ispitanici podijeljeni na one koji se slabo pridržavaju (<4 stupnja) i one koji se umjereno do visoko pridržavaju (_4 stupnja). Razgovarali smo sa sto i sedamnaest sudionika od svibnja 2004 do lipnja 2005. godine, a njihova mjerenja lipida izdvojena su iz elektronske baze podataka. Vrijednosti ukupnog kolesterola, HDL-kolesterola, LDL-kolesterola i triglicerida najznačajnije su porasli u prvih tri do šest mjeseci nakon otpočinjanja liječenja HAART-om (prosječno povećanje u prva 3 mjeseca je: 25% za ukupni kolesterol, 22% za LDL-kolesterol, 18% za HDL-kolesterol i 43% za trigliceride). Mediteranska prehrana i fizička aktivnost nisu utjecale na razine lipida u serumu. Srednje vrijednosti ukupnog kolesterola bile su više u sudionika koji su liječeni kombinacijom nenukleozidnog inhibitora reverzne transkripraze i inhibitora proteaze ako se usporedi sa sudionicima koji su liječeni nukleozidnim analozima sa nenukleozidnim analozima ili kombinacijom nukleozidnih analoga i inhibitora proteaze. Između pojedinih lijekova, liječenje indinavirom/ritonavirom imalo je najnepovoljniji profil lipida.

Item Type: Article
MeSH: Adult ; Antiretroviral Therapy, Highly Active ; Croatia/epidemiology ; Diet, Mediterranean ; Dyslipidemias/diet therapy ; Dyslipidemias/epidemiology ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Questionnaires ; Risk Factors
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Turčinov, DragoUNSPECIFIED
Stanley, ChristineUNSPECIFIED
Canchola, Jesse A.UNSPECIFIED
Rutherford, George W.UNSPECIFIED
Novotny, Thomas E.UNSPECIFIED
Begovac, JosipUNSPECIFIED
Date: June 2009
Date Deposited: 23 Sep 2009
Last Modified: 23 Sep 2011 16:11
Subjects: /
Related URLs:
    URI: http://medlib.mef.hr/id/eprint/637

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