Dyslipidemia and adherence to the Mediterranean diet in Croatian HIV-infected patients during the first year of highly active antiretroviral therapy [Dislipidemija i pridržavanje mediteranskoj prehrani u bolesnika iz Hrvatske za vrijeme prve godine liječenja vrlo djelotvornom antiretrovirusnom terapijom]

Turčinov, Drago and Stanley, Christine and Canchola, Jesse A. and Rutherford, George W. and Novotny, Thomas E. and Begovac, Josip (2009) Dyslipidemia and adherence to the Mediterranean diet in Croatian HIV-infected patients during the first year of highly active antiretroviral therapy [Dislipidemija i pridržavanje mediteranskoj prehrani u bolesnika iz Hrvatske za vrijeme prve godine liječenja vrlo djelotvornom antiretrovirusnom terapijom]. Collegium Antropologicum, 33 (2). pp. 423-430. ISSN 0350-6134

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Abstract

We investigated the association of adherence to the Mediterranean diet and other risk factors for dyslipidemia in HIV-infected Croatian patients during the first year of highly active antiretroviral therapy (HAART). Adherence to the Mediterranean diet was determined by a 150-item questionnaire; a 0 to 9-point diet scale was created that stratified respondents as having low adherence (<4 points) and moderate to high adherence (> or = 4 points). We interviewed 117 participants between May 2004 and June 2005 and abstracted their serum lipid measurements taken during the first year of HAART The values of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides increased most prominently in the first 3 to 6 months after initiation of HAART (average increase at 3 months: 25% for total cholesterol, 22% for LDL-cholesterol, 18% for HDL-cholesterol and 43% for triglycerides). A Mediterranean diet and physical activity had no effect on serum lipids. The mean total cholesterol was higher in participants receiving a combination of a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor compared to participants receiving a combination of nucleoside analogs with a non-nucleoside analog or a combination of nucleoside analogs and a protease inhibitor Among individual drug treatments, indinavir/ritonavir had the most unfavorable lipid profile. We conclude that adherence to a Mediterranean diet does not influence serum lipid profiles during the first year of HAART.

Abstract in Croatian

Istražili smo pridržavanje mediteranskoj prehrani i druge rizične čimbenike koji su povezani s dislipidemijom u bolesnika zaraženih HIV-om iz Hrvatske za vrijeme prve godine liječenja vrlo djelotvornom antiretrovirusnom terapijom (HAART). Pridržavanje mediteranskoj prehrani određeno je upitnikom od 150 pitanja; učinjena je skala od 0 do 9 stupnjeva po kojoj su ispitanici podijeljeni na one koji se slabo pridržavaju (<4 stupnja) i one koji se umjereno do visoko pridržavaju (_4 stupnja). Razgovarali smo sa sto i sedamnaest sudionika od svibnja 2004 do lipnja 2005. godine, a njihova mjerenja lipida izdvojena su iz elektronske baze podataka. Vrijednosti ukupnog kolesterola, HDL-kolesterola, LDL-kolesterola i triglicerida najznačajnije su porasli u prvih tri do šest mjeseci nakon otpočinjanja liječenja HAART-om (prosječno povećanje u prva 3 mjeseca je: 25% za ukupni kolesterol, 22% za LDL-kolesterol, 18% za HDL-kolesterol i 43% za trigliceride). Mediteranska prehrana i fizička aktivnost nisu utjecale na razine lipida u serumu. Srednje vrijednosti ukupnog kolesterola bile su više u sudionika koji su liječeni kombinacijom nenukleozidnog inhibitora reverzne transkripraze i inhibitora proteaze ako se usporedi sa sudionicima koji su liječeni nukleozidnim analozima sa nenukleozidnim analozima ili kombinacijom nukleozidnih analoga i inhibitora proteaze. Između pojedinih lijekova, liječenje indinavirom/ritonavirom imalo je najnepovoljniji profil lipida.

Item Type: Article
MeSH: Adult ; Antiretroviral Therapy, Highly Active ; Croatia/epidemiology ; Diet, Mediterranean ; Dyslipidemias/diet therapy ; Dyslipidemias/epidemiology ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Questionnaires ; Risk Factors
Departments: Katedra za infektologiju
Depositing User: Marijan Šember
Status: Published
Creators:
CreatorsEmail
Turčinov, DragoUNSPECIFIED
Stanley, ChristineUNSPECIFIED
Canchola, Jesse A.UNSPECIFIED
Rutherford, George W.UNSPECIFIED
Novotny, Thomas E.UNSPECIFIED
Begovac, JosipUNSPECIFIED
Date: June 2009
Date Deposited: 23 Sep 2009
Last Modified: 24 Mar 2020 11:59
Subjects: /
Related URLs:
URI: http://medlib.mef.hr/id/eprint/637

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