Repozitorij Medicinskog fakulteta Sveučilišta u Zagrebu

Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia

Rojnić Kuzman, Martina and Medved, Vesna and Terzić, Janoš and Krainc, Dimitri (2009) Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia. Journal of Psychiatric Research, 43 (13). pp. 1073-1077. ISSN 0022-3956

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    English abstract

    The aim of this study was to analyze gene expression in blood of patients with newly-diagnosed schizophrenia during their first psychotic episode and subsequent remission. Whole blood samples were obtained from 32 untreated patients presenting with their first psychotic episode suggestive of schizophrenia and 32 age- and gender- matched controls. Using Affymetrix micoarrays, we identified significantly altered expression of 180 gene probes in psychotic patients compared to controls. A subset of 4 significantly changed genes was further confirmed with QRT PCR. The following genes were significantly altered in patients: glucose transporter, SLC2A3 (p<0.001) and actin assembly factor DAAM2 (p<0.001) were increased, whereas translation, zinc metallopeptidase, neurolysin 1 and myosin C were significantly decreased (p<0.05). Expression of these candidate markers was also analyzed in a longitudinal study (12-24 months) in 12 patients who achieved full remission. Interestingly, expression of DAAM2 returned to control levels in patients who were in remission after their first psychotic episode, suggesting that its expression correlates with diseases progression and/or response to treatment. In summary, we identified changes of gene expression from peripheral blood which might help discriminate patients with schizophrenia from controls. While these results are promising, especially for DAAM2 whose polymorphic variants have been found significantly associated with schizophrenia, it will be important to analyze larger cohorts of patients in order to firmly establish changes in gene expression as blood markers of schizophrenia.

    Item Type: Article
    Divisions: Katedra za psihijatriju i psihološku medicinu
    Depositing User: Marijan Šember
    Status: Published
    Creators:
    CreatorsEmail
    Rojnić Kuzman, Martina
    Medved, Vesna
    Terzić, Janoš
    Krainc, Dimitri
    Date: September 2009
    Date Deposited: 04 Sep 2009
    Last Modified: 23 Sep 2011 18:10
    Subjects: /
    Related URLs:
      URI: http://medlib.mef.hr/id/eprint/601

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